Fractional Flow Reserve Derived from CT: The State of Play in 2020

Overview

Journal Radiol Cardiothorac Imaging

Specialty Cardiology & Vascular Diseases

Date 2021 Mar 29

PMID 33778538

Citations 2

Authors

Jonathan R Weir-McCall

Timothy A Fairbairn

Affiliations

Soon will be listed here.

Abstract

Fractional flow reserve derived from CT is a rapidly developing technique, with an increasing burden of literature supporting its potential role in the workup of patients suspected of having coronary artery disease.

Citing Articles

Rapid and Precise Computation of Fractional Flow Reserve from Routine Two-Dimensional Coronary Angiograms Based on Fluid Mechanics: The Pilot FFR2D Study.

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Coronary Artery Vorticity to Predict Functional Plaque Progression in Participants with Type 2 Diabetes Mellitus.

Tomizawa N, Fujimoto S, Mita T, Takahashi D, Nozaki Y, Fan R Radiol Cardiothorac Imaging. 2023; 5(4):e230016.

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References

Knuuti J, Ballo H, Juarez-Orozco L, Saraste A, Kolh P, Rutjes A . The performance of non-invasive tests to rule-in and rule-out significant coronary artery stenosis in patients with stable angina: a meta-analysis focused on post-test disease probability. Eur Heart J. 2018; 39(35):3322-3330. DOI: 10.1093/eurheartj/ehy267. View

Lu M, Ferencik M, Roberts R, Lee K, Ivanov A, Adami E . Noninvasive FFR Derived From Coronary CT Angiography: Management and Outcomes in the PROMISE Trial. JACC Cardiovasc Imaging. 2017; 10(11):1350-1358. PMC: 5632098. DOI: 10.1016/j.jcmg.2016.11.024. View

Kueh S, Mooney J, Ohana M, Kim U, Blanke P, Grover R . Fractional flow reserve derived from coronary computed tomography angiography reclassification rate using value distal to lesion compared to lowest value. J Cardiovasc Comput Tomogr. 2017; 11(6):462-467. DOI: 10.1016/j.jcct.2017.09.009. View

Corcoran D, Young R, Adlam D, McConnachie A, Mangion K, Ripley D . Coronary microvascular dysfunction in patients with stable coronary artery disease: The CE-MARC 2 coronary physiology sub-study. Int J Cardiol. 2018; 266:7-14. PMC: 6008494. DOI: 10.1016/j.ijcard.2018.04.061. View

Kitabata H, Leipsic J, Patel M, Nieman K, De Bruyne B, Rogers C . Incidence and predictors of lesion-specific ischemia by FFR: Learnings from the international ADVANCE registry. J Cardiovasc Comput Tomogr. 2018; 12(2):95-100. DOI: 10.1016/j.jcct.2018.01.008. View

Morris P, Narracott A, von Tengg-Kobligk H, Silva Soto D, Hsiao S, Lungu A . Computational fluid dynamics modelling in cardiovascular medicine. Heart. 2015; 102(1):18-28. PMC: 4717410. DOI: 10.1136/heartjnl-2015-308044. View

Lee J, Koo B, Shin E, Nam C, Doh J, Hwang D . Clinical implications of three-vessel fractional flow reserve measurement in patients with coronary artery disease. Eur Heart J. 2017; 39(11):945-951. DOI: 10.1093/eurheartj/ehx458. View

Matsumura M, Johnson N, Fearon W, Mintz G, Stone G, Oldroyd K . Accuracy of Fractional Flow Reserve Measurements in Clinical Practice: Observations From a Core Laboratory Analysis. JACC Cardiovasc Interv. 2017; 10(14):1392-1401. DOI: 10.1016/j.jcin.2017.03.031. View

Ihdayhid A, White A, Ko B . Assessment of Serial Coronary Stenoses With Noninvasive Computed Tomography-Derived Fractional Flow Reserve and Treatment Planning Using a Novel Virtual Stenting Application. JACC Cardiovasc Interv. 2017; 10(24):e223-e225. DOI: 10.1016/j.jcin.2017.09.015. View

10.

Fairbairn T, Nieman K, Akasaka T, Norgaard B, Berman D, Raff G . Real-world clinical utility and impact on clinical decision-making of coronary computed tomography angiography-derived fractional flow reserve: lessons from the ADVANCE Registry. Eur Heart J. 2018; 39(41):3701-3711. PMC: 6215963. DOI: 10.1093/eurheartj/ehy530. View

11.

Renard B, Cami E, Jiddou-Patros M, Said A, Kado H, Trivax J . Optimizing the Technique for Invasive Fractional Flow Reserve to Assess Lesion-Specific Ischemia. Circ Cardiovasc Interv. 2019; 12(10):e007939. DOI: 10.1161/CIRCINTERVENTIONS.119.007939. View

12.

Lee J, Layland J, Jung J, Lee H, Echavarria-Pinto M, Watkins S . Integrated physiologic assessment of ischemic heart disease in real-world practice using index of microcirculatory resistance and fractional flow reserve: insights from the International Index of Microcirculatory Resistance Registry. Circ Cardiovasc Interv. 2015; 8(11):e002857. DOI: 10.1161/CIRCINTERVENTIONS.115.002857. View

13.

Blanco P, Bulant C, Muller L, Maso Talou G, Bezerra C, Lemos P . Comparison of 1D and 3D Models for the Estimation of Fractional Flow Reserve. Sci Rep. 2018; 8(1):17275. PMC: 6250665. DOI: 10.1038/s41598-018-35344-0. View

14.

Lee J, Choi G, Koo B, Hwang D, Park J, Zhang J . Identification of High-Risk Plaques Destined to Cause Acute Coronary Syndrome Using Coronary Computed Tomographic Angiography and Computational Fluid Dynamics. JACC Cardiovasc Imaging. 2018; 12(6):1032-1043. DOI: 10.1016/j.jcmg.2018.01.023. View

15.

Norgaard B, Leipsic J, Gaur S, Seneviratne S, Ko B, Ito H . Diagnostic performance of noninvasive fractional flow reserve derived from coronary computed tomography angiography in suspected coronary artery disease: the NXT trial (Analysis of Coronary Blood Flow Using CT Angiography: Next Steps). J Am Coll Cardiol. 2014; 63(12):1145-1155. DOI: 10.1016/j.jacc.2013.11.043. View

16.

Celeng C, Leiner T, Maurovich-Horvat P, Merkely B, de Jong P, Dankbaar J . Anatomical and Functional Computed Tomography for Diagnosing Hemodynamically Significant Coronary Artery Disease: A Meta-Analysis. JACC Cardiovasc Imaging. 2018; 12(7 Pt 2):1316-1325. DOI: 10.1016/j.jcmg.2018.07.022. View

17.

Ihdayhid A, Norgaard B, Gaur S, Leipsic J, Nerlekar N, Osawa K . Prognostic Value and Risk Continuum of Noninvasive Fractional Flow Reserve Derived from Coronary CT Angiography. Radiology. 2019; 292(2):343-351. DOI: 10.1148/radiol.2019182264. View

18.

Newby D, Adamson P, Berry C, Boon N, Dweck M, Flather M . Coronary CT Angiography and 5-Year Risk of Myocardial Infarction. N Engl J Med. 2018; 379(10):924-933. DOI: 10.1056/NEJMoa1805971. View

19.

Norgaard B, Terkelsen C, Mathiassen O, Grove E, Botker H, Parner E . Coronary CT Angiographic and Flow Reserve-Guided Management of Patients With Stable Ischemic Heart Disease. J Am Coll Cardiol. 2018; 72(18):2123-2134. DOI: 10.1016/j.jacc.2018.07.043. View

20.

Jensen J, Botker H, Mathiassen O, Grove E, Ovrehus K, Pedersen K . Computed tomography derived fractional flow reserve testing in stable patients with typical angina pectoris: influence on downstream rate of invasive coronary angiography. Eur Heart J Cardiovasc Imaging. 2017; 19(4):405-414. PMC: 5915944. DOI: 10.1093/ehjci/jex068. View