Targeting Redox-altered Plasticity to Reactivate Synaptic Function: A Novel Therapeutic Strategy for Cognitive Disorder

Overview

Journal Acta Pharm Sin B

Publisher Elsevier

Specialty Pharmacology

Date 2021 Mar 29

PMID 33777670

Citations 13

Authors

Pei Wang

Fang Wang

Lan Ni

Pengfei Wu

Jianguo Chen

Affiliations

Soon will be listed here.

Abstract

Redox-altered plasticity refers to redox-dependent reversible changes in synaptic plasticity altering functions of key proteins, such as -methyl-d-aspartate receptor (NMDAR). Age-related cognitive disorders includes Alzheimer's disease (AD), vascular dementia (VD), and age-associated memory impairment (AAMI). Based on the critical role of NMDAR-dependent long-term potentiation (LTP) in memory, the increase of reactive oxygen species in cognitive disorders, and the sensitivity of NMDAR to the redox status, converging lines have suggested the redox-altered NMDAR-dependent plasticity might underlie the synaptic dysfunctions associated with cognitive disorders. In this review, we summarize the involvement of redox-altered plasticity in cognitive disorders by presenting the available evidence. According to reports from our laboratory and other groups, this "redox-altered plasticity" is more similar to functional changes rather than organic injuries, and strategies targeting redox-altered plasticity using pharmacological agents might reverse synaptic dysfunctions and memory abnormalities in the early stage of cognitive disorders. Targeting redox modifications for NMDARs may serve as a novel therapeutic strategy for memory deficits.

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