The Ying and Yang of Hydrogen Sulfide As a Paracrine/Autocrine Agent in Neurodegeneration: Focus on Amyotrophic Lateral Sclerosis

Overview

Journal Cells

Publisher MDPI

Specialties Biochemistry
Biophysics
Cell Biology
Molecular Biology

Date 2023 Jul 14

PMID 37443723

Authors

Alida Spalloni

Susanna De Stefano

Juliette Gimenez

Viviana Greco

Nicola B Mercuri

Valerio Chiurchiu

Patrizia Longone

Affiliations

Soon will be listed here.

Abstract

Ever since its presence was reported in the brain, the nature and role of hydrogen sulfide (HS) in the Central Nervous System (CNS) have changed. Consequently, HS has been elected as the third gas transmitter, along with carbon monoxide and nitric oxide, and a number of studies have focused on its neuromodulatory and protectant functions in physiological conditions. The research on HS has highlighted its many facets in the periphery and in the CNS, and its role as a double-faced compound, switching from protective to toxic depending on its concentration. In this review, we will focus on the bell-shaped nature of HS as an angiogenic factor and as a molecule released by glial cells (mainly astrocytes) and non-neuronal cells acting on the surrounding environment (paracrine) or on the releasing cells themselves (autocrine). Finally, we will discuss its role in Amyotrophic Lateral Sclerosis, a paradigm of a neurodegenerative disease.

Citing Articles

Hydrogen Sulfide Modulates Astrocytic Toxicity in Mouse Spinal Cord Cultures: Implications for Amyotrophic Lateral Sclerosis.

De Stefano S, Tiberi M, Salvatori I, De Bardi M, Gimenez J, Pirshayan M Antioxidants (Basel). 2024; 13(10).

PMID: 39456494 PMC: 11504967. DOI: 10.3390/antiox13101241.

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