Neuropsin-dependent and -independent Behavioral Tagging

Overview

Journal Neuropsychopharmacol Rep

Specialties Neurology
Pharmacology

Date 2021 Mar 27

PMID 33773089

Citations 1

Authors

Yuka Suzuki

Yuya Yoda

Yasuyuki Ishikawa

Affiliations

Soon will be listed here.

Abstract

Aim: The consolidation of short-term memories into long-term memories is promoted by associations with novel environmental stimuli. This phenomenon is known as behavioral tagging. Neuropsin, a plasticity-related serine protease in the hippocampus and amygdala, is involved in memory formation. This study investigated how neuropsin affects associative long-term memory.

Methods: Short-term and long-term memory were assessed in control and neuropsin-deficient mice by investigating their performance in inhibitory avoidance and spatial object recognition tasks. The effect of exposure to novelty on the conversion of short-term memory to associative long-term memory was also examined.

Results: The consolidation of task-related short-term memories into long-term memories was facilitated by exposing the animals to a novel environment 1 hour before training. However, this long-term memory conversion was impaired in neuropsin-deficient mice performing the inhibitory avoidance task but not the spatial object recognition task.

Conclusion: Behavioral tagging occurs via neuropsin-dependent and neuropsin-independent processes for different behavioral tasks.

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Neuropsin-dependent and -independent behavioral tagging.

Suzuki Y, Yoda Y, Ishikawa Y Neuropsychopharmacol Rep. 2021; 41(2):215-222.

PMID: 33773089 PMC: 8340819. DOI: 10.1002/npr2.12177.

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