IFNAR1 Signaling in NK Cells Promotes Persistent Virus Infection

Overview

Journal Sci Adv

Specialties Biology
Science

Date 2021 Mar 27

PMID 33771858

Citations 9

Authors

Zhe Huang

Seung Goo Kang

Yunqiao Li

Jaroslav Zak

Namir Shaabani

Kaiyuan Deng

Jovan Shepherd

Raag Bhargava

John R Teijaro

Changchun Xiao

Affiliations

Soon will be listed here.

Abstract

Inhibition of type 1 interferon (IFN-I) signaling promotes the control of persistent virus infection, but the underlying mechanisms remain poorly understood. Here, we report that genetic ablation of specifically in natural killer (NK) cells led to elevated numbers of T follicular helper cells, germinal center B cells, and plasma cells and improved antiviral T cell function, resulting in hastened virus clearance that was comparable to IFNAR1 neutralizing antibody treatment. Antigen-specific B cells and antiviral antibodies were essential for the accelerated control of LCMV Cl13 infection following IFNAR1 blockade. IFNAR1 signaling in NK cells promoted NK cell function and general killing of antigen-specific CD4 and CD8 T cells. Therefore, inhibition of IFN-I signaling in NK cells enhances CD4 and CD8 T cell responses, promotes humoral immune responses, and thereby facilitates the control of persistent virus infection.

Citing Articles

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