Deficiency of MMP1a (Matrix Metalloprotease 1a) Collagenase Suppresses Development of Atherosclerosis in Mice: Translational Implications for Human Coronary Artery Disease

Overview

Journal Arterioscler Thromb Vasc Biol

Date 2021 Mar 25

PMID 33761760

Citations 6

Authors

Elizabeth K Fletcher

Yanling Wang

Laura K Flynn

Susan E Turner

Jeffrey J Rade

Carey D Kimmelstiel

Paul A Gurbel

Kevin P Bliden

Lidija Covic

Athan Kuliopulos

Affiliations

Soon will be listed here.

Abstract

[Figure: see text].

Citing Articles

Macrophage-based pathogenesis and theranostics of vulnerable plaques.

Fang F, Wang E, Fang M, Yue H, Yang H, Liu X Theranostics. 2025; 15(4):1570-1588.

PMID: 39816684 PMC: 11729549. DOI: 10.7150/thno.105256.

Multiplex proteomics identifies inflammation-related plasma biomarkers for aging and cardio-metabolic disorders.

Wu S, Li Y, Zhao X, Shi F, Chen J Clin Proteomics. 2024; 21(1):30.

PMID: 38649851 PMC: 11036613. DOI: 10.1186/s12014-024-09480-x.

Recent Advances in Anti-Atherosclerosis and Potential Therapeutic Targets for Nanomaterial-Derived Drug Formulations.

Xiao Z, Li Y, Xiong L, Liao J, Gao Y, Luo Y Adv Sci (Weinh). 2023; 10(29):e2302918.

PMID: 37698552 PMC: 10582432. DOI: 10.1002/advs.202302918.

Suppression of Heart Failure With PAR1 Pepducin Technology in a Pressure Overload Model in Mice.

Fletcher E, Ngwenyama N, Nguyen N, Turner S, Covic L, Alcaide P Circ Heart Fail. 2023; 16(10):e010621.

PMID: 37477012 PMC: 10592519. DOI: 10.1161/CIRCHEARTFAILURE.123.010621.

Inflammation, Microcalcification, and Increased Expression of Osteopontin Are Histological Hallmarks of Plaque Vulnerability in Patients with Advanced Carotid Artery Stenosis.

Balmos I, Horvath E, Brinzaniuc K, Muresan A, Olah P, Molnar G Biomedicines. 2023; 11(3).

PMID: 36979863 PMC: 10045225. DOI: 10.3390/biomedicines11030881.

References

Gurbel P, Bliden K, Turner S, Tantry U, Gesheff M, Barr T . Cell-Penetrating Pepducin Therapy Targeting PAR1 in Subjects With Coronary Artery Disease. Arterioscler Thromb Vasc Biol. 2015; 36(1):189-97. PMC: 4836853. DOI: 10.1161/ATVBAHA.115.306777. View

Morgan A, Rerkasem K, Gallagher P, Zhang B, Morris G, Calder P . Differences in matrix metalloproteinase-1 and matrix metalloproteinase-12 transcript levels among carotid atherosclerotic plaques with different histopathological characteristics. Stroke. 2004; 35(6):1310-5. DOI: 10.1161/01.STR.0000126822.01756.99. View

Trivedi V, Boire A, Tchernychev B, Kaneider N, Leger A, OCallaghan K . Platelet matrix metalloprotease-1 mediates thrombogenesis by activating PAR1 at a cryptic ligand site. Cell. 2009; 137(2):332-43. PMC: 2807741. DOI: 10.1016/j.cell.2009.02.018. View

Sukhova G, Schonbeck U, Rabkin E, Schoen F, Poole A, Billinghurst R . Evidence for increased collagenolysis by interstitial collagenases-1 and -3 in vulnerable human atheromatous plaques. Circulation. 1999; 99(19):2503-9. DOI: 10.1161/01.cir.99.19.2503. View

Daugherty A, Tall A, Daemen M, Falk E, Fisher E, Garcia-Cardena G . Recommendation on Design, Execution, and Reporting of Animal Atherosclerosis Studies: A Scientific Statement From the American Heart Association. Arterioscler Thromb Vasc Biol. 2017; 37(9):e131-e157. DOI: 10.1161/ATV.0000000000000062. View

Austin K, Nguyen N, Javid G, Covic L, Kuliopulos A . Noncanonical matrix metalloprotease-1-protease-activated receptor-1 signaling triggers vascular smooth muscle cell dedifferentiation and arterial stenosis. J Biol Chem. 2013; 288(32):23105-15. PMC: 3743483. DOI: 10.1074/jbc.M113.467019. View

Jung K, Kim P, Leuschner F, Gorbatov R, Kim J, Ueno T . Endoscopic time-lapse imaging of immune cells in infarcted mouse hearts. Circ Res. 2013; 112(6):891-9. PMC: 3834270. DOI: 10.1161/CIRCRESAHA.111.300484. View

Gearing A, Beckett P, Christodoulou M, Churchill M, Clements J, Davidson A . Processing of tumour necrosis factor-alpha precursor by metalloproteinases. Nature. 1994; 370(6490):555-7. DOI: 10.1038/370555a0. View

Tressel S, Kaneider N, Kasuda S, Foley C, Koukos G, Austin K . A matrix metalloprotease-PAR1 system regulates vascular integrity, systemic inflammation and death in sepsis. EMBO Mol Med. 2011; 3(7):370-84. PMC: 3394510. DOI: 10.1002/emmm.201100145. View

10.

Zhang P, Gruber A, Kasuda S, Kimmelstiel C, OCallaghan K, Cox D . Suppression of arterial thrombosis without affecting hemostatic parameters with a cell-penetrating PAR1 pepducin. Circulation. 2012; 126(1):83-91. PMC: 3423084. DOI: 10.1161/CIRCULATIONAHA.112.091918. View

11.

Quillard T, Araujo H, Franck G, Tesmenitsky Y, Libby P . Matrix metalloproteinase-13 predominates over matrix metalloproteinase-8 as the functional interstitial collagenase in mouse atheromata. Arterioscler Thromb Vasc Biol. 2014; 34(6):1179-86. PMC: 4123424. DOI: 10.1161/ATVBAHA.114.303326. View

12.

Vandenbroucke R, Libert C . Is there new hope for therapeutic matrix metalloproteinase inhibition?. Nat Rev Drug Discov. 2014; 13(12):904-27. DOI: 10.1038/nrd4390. View

13.

Newby A . Metalloproteinase expression in monocytes and macrophages and its relationship to atherosclerotic plaque instability. Arterioscler Thromb Vasc Biol. 2008; 28(12):2108-14. DOI: 10.1161/ATVBAHA.108.173898. View

14.

Austin K, Covic L, Kuliopulos A . Matrix metalloproteases and PAR1 activation. Blood. 2012; 121(3):431-9. PMC: 3548166. DOI: 10.1182/blood-2012-09-355958. View

15.

Gurbel P, Kuliopulos A, Tantry U . G-protein-coupled receptors signaling pathways in new antiplatelet drug development. Arterioscler Thromb Vasc Biol. 2015; 35(3):500-12. PMC: 4836833. DOI: 10.1161/ATVBAHA.114.303412. View

16.

Young D, Das N, Anowai A, Dufour A . Matrix Metalloproteases as Influencers of the Cells' Social Media. Int J Mol Sci. 2019; 20(16). PMC: 6720954. DOI: 10.3390/ijms20163847. View

17.

Laxton R, Hu Y, Duchene J, Zhang F, Zhang Z, Leung K . A role of matrix metalloproteinase-8 in atherosclerosis. Circ Res. 2009; 105(9):921-9. PMC: 2853782. DOI: 10.1161/CIRCRESAHA.109.200279. View

18.

Foley C, Luo C, OCallaghan K, Hinds P, Covic L, Kuliopulos A . Matrix metalloprotease-1a promotes tumorigenesis and metastasis. J Biol Chem. 2012; 287(29):24330-8. PMC: 3397859. DOI: 10.1074/jbc.M112.356303. View

19.

Deguchi J, Aikawa E, Libby P, Vachon J, Inada M, Krane S . Matrix metalloproteinase-13/collagenase-3 deletion promotes collagen accumulation and organization in mouse atherosclerotic plaques. Circulation. 2005; 112(17):2708-15. DOI: 10.1161/CIRCULATIONAHA.105.562041. View

20.

Lemaitre V, OByrne T, Borczuk A, Okada Y, Tall A, DArmiento J . ApoE knockout mice expressing human matrix metalloproteinase-1 in macrophages have less advanced atherosclerosis. J Clin Invest. 2001; 107(10):1227-34. PMC: 209293. DOI: 10.1172/JCI9626. View