The YYRR Box: a Conserved Dipyrimidine-dipurine Sequence Element in Drosophila and Other Eukaryotes

Overview

Journal Nucleic Acids Res

Publisher Oxford University Press

Specialty Biochemistry

Date 1988 Apr 25

PMID 3375058

Citations 2

Authors

D Cavener

Y Feng

B Foster

P Krasney

M Murtha

C Schonbaum

X Xiao

Affiliations

Soon will be listed here.

Abstract

We have discovered a novel DNA sequence element in Drosophila which is based upon a CTGA tandem repeat. This element has been named the YYRR box to emphasize its dipyrimidine-dipurine nature which is predicted to have unusual structural features. Southern hybridization analysis of genomic DNA indicates the presence of 25-30 copies of the YYRR box in each of three Drosophila species (melanogaster, pseudoobscura, and virilis) and conservation of genomic location within species. Similar analysis of human and rat DNA indicates the presence of YYRR related sequences in mammals as well. YYRR boxes have been localized to two genetic loci in Drosophila: Gld and a gene tentative identified as ted. These two genes exhibit correlated patterns of developmental expression and an identical mutant phenotype. Sequence analysis of the Gld YYRR box in three Drosophila species revealed a high degree of conservation despite its intronic location.

Citing Articles

Molecular structure and transformation of the glucose dehydrogenase gene in Drosophila melanogaster.

Whetten R, Organ E, Krasney P, Cox-Foster D, Cavener D Genetics. 1988; 120(2):475-84.

PMID: 3143620 PMC: 1203525. DOI: 10.1093/genetics/120.2.475.

Potential genetic functions of tandem repeated DNA sequence blocks in the human genome are based on a highly conserved "chromatin folding code".

Vogt P Hum Genet. 1990; 84(4):301-36.

PMID: 2407640 DOI: 10.1007/BF00196228.

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