Tissue-specific Immunity for a Changing World

Overview

Journal Cell

Publisher Cell Press

Specialty Cell Biology

Date 2021 Mar 19

PMID 33740452

Citations 43

Authors

Stuart P Weisberg

Basak B Ural

Donna L Farber

Affiliations

Soon will be listed here.

Abstract

Our immune system has evolved to protect us from pathogens and maintain homeostasis through localization in diverse tissue sites throughout the body. Immune responses are orchestrated by T cells, which direct pathogen clearance at the infection site and establish tissue-resident memory T cells (TRMs) for protection immunity. Here, we discuss how tissue immune responses are influenced by various stressors (e.g., metabolic, environmental, aging) that are rapidly changing due to climate fluctuations and globalization. We propose potential strategies for targeting tissue immunity to mitigate future pathogenic and environmental challenges and areas of investigation that can elucidate mechanisms for adapting and restoring homeostasis.

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