Effects of Lipoic Acid Supplementation on Age- and Iron-induced Memory Impairment, Mitochondrial DNA Damage and Antioxidant Responses

Overview

Journal Eur J Nutr

Specialty Nutritional Sciences

Date 2021 Mar 19

PMID 33738535

Citations 8

Authors

Patricia Molz

Betania Souza de Freitas

Vanise Hallas Uberti

Kesiane Mayra da Costa

Luiza Wilges Kist

Mauricio Reis Bogo

Nadja Schroder

Affiliations

Soon will be listed here.

Abstract

Purpose: To investigate the effects of lipoic acid (LA) supplementation during adulthood combined with supplementation later in life or LA administration only at old age on age-induced cognitive dysfunction, mitochondrial DNA deletions, caspase 3 and antioxidant response enzymes expression in iron-treated rats.

Methods: Male rats were submitted to iron treatment (30 mg/kg body wt of Carbonyl iron) from 12 to 14th post-natal days. Iron-treated rats received LA supplementation (50 mg/kg, daily) in adulthood and old age or at old age only for 21 days. Memory, mitochondrial DNA (mtDNA) complex I deletions, caspase 3 mRNA expression and antioxidant response enzymes mRNA expression were analyzed in the hippocampus.

Results: LA administration in adulthood combined with treatment later in life was able to reverse age-induced effects on object recognition and inhibitory avoidance memory, as well as on mtDNA deletions, nuclear factor (erythroid-derived 2)-like 2 (Nrf2) expression, and antioxidant enzymes disruption induced by iron in aged rats. LA treatment only at old age reversed iron-induced effects to a lesser extent when compared to the combined treatment.

Conclusion: The present findings support the view that LA supplementation may be considered as an adjuvant against mitochondrial damage and cognitive decline related to aging and neurodegenerative disorders.

Citing Articles

Effects of the AMPAR Antagonist, Perampanel, on Cognitive Function in Rats Exposed to Neonatal Iron Overload.

da Silva J, de Souza L, Severo M, Rodrigues S, Molz P, Schonhofen P Mol Neurobiol. 2024; 61(12):10083-10096.

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A high fat diet potentiates neonatal iron overload-induced memory impairments in rats.

do Nascimento F, de Freitas B, Dos Passos M, Kleverston L, de Souza Dos Santos C, Kist L Eur J Nutr. 2024; 63(4):1163-1175.

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Dietary pro-oxidant score (POS) and cardio-metabolic panel among obese individuals: a cross-sectional study.

Nikrad N, Shakarami A, Rahimi Z, Janghorbanian-Poodeh R, Farhangi M, Hosseini B BMC Endocr Disord. 2023; 23(1):144.

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Alpha-Lipoic Acid Supplementation Restores Early Age-Related Sensory and Endothelial Dysfunction in the Skin.

de Bengy A, Decorps J, Martin L, Pagnon A, Chevalier F, Sigaudo-Roussel D Biomedicines. 2022; 10(11).

PMID: 36359407 PMC: 9687533. DOI: 10.3390/biomedicines10112887.

Iron Metabolism in Aging and Age-Related Diseases.

Tian Y, Tian Y, Yuan Z, Zeng Y, Wang S, Fan X Int J Mol Sci. 2022; 23(7).

PMID: 35408967 PMC: 8998315. DOI: 10.3390/ijms23073612.

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