Effects of Two Consecutive Mixed Meals High in Palmitic Acid or Stearic Acid on 8-h Postprandial Lipemia and Glycemia in Healthy-weight and Overweight Men and Postmenopausal Women: a Randomized Controlled Trial

Overview

Journal Eur J Nutr

Specialty Nutritional Sciences

Date 2021 Mar 18

PMID 33733339

Citations 4

Authors

Merel A van Rooijen

Jogchum Plat

Peter L Zock

Wendy A M Blom

Ronald P Mensink

Affiliations

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Abstract

Purpose: Palmitic and stearic acids have different effects on fasting serum lipoproteins. However, the effects on postprandial lipemia and glycemia are less clear. Also, the effects of a second meal may differ from those of the first meal. Therefore, we studied the effects of two consecutive mixed meals high in palmitic acid- or stearic acid-rich fat blends on postprandial lipemia and glycemia.

Methods: In a randomized, crossover study, 32 participants followed 4-week diets rich in palmitic or stearic acids, At the end of each dietary period, participants consumed two consecutive meals each containing ± 50 g of the corresponding fat blend.

Results: Postprandial concentrations of triacylglycerol (diet-effect: - 0.18 mmol/L; p = 0.001) and apolipoprotein B48 (diet-effect: - 0.68 mg/L; p = 0.002) were lower after stearic-acid than after palmitic-acid intake. Consequently, total (iAUC) and first meal (iAUC) responses were lower after stearic-acid intake (p ≤ 0.01). Second meal responses (iAUC) were not different. Postprandial changes between the diets in non-esterified fatty acids (NEFA) and C-peptide differed significantly over time (p < 0.001 and p = 0.020 for diet*time effects, respectively), while those for glucose and insulin did not. The dAUC, dAUC, and dAUC for NEFA were larger after stearic-acid intake (p ≤ 0.05). No differences were observed in the iAUCs of C-peptide, glucose, and insulin. However, second meal responses for glucose and insulin (iAUC tended to be lower after stearic-acid intake (p < 0.10).

Conclusion: Consumption of the stearic acid-rich meals lowered postprandial lipemia as compared with palmitic acid. After the second stearic acid-rich meal, concentrations of C-peptide peaked earlier and those of NEFA decreased more. Clinical trial registry This trial was registered at clinicaltrials.gov as NCT02835651 on July 18, 2016.

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References

Pirillo A, Norata G, Catapano A . Postprandial lipemia as a cardiometabolic risk factor. Curr Med Res Opin. 2014; 30(8):1489-503. DOI: 10.1185/03007995.2014.909394. View

Fava S . Role of postprandial hyperglycemia in cardiovascular disease. Expert Rev Cardiovasc Ther. 2008; 6(6):859-72. DOI: 10.1586/14779072.6.6.859. View

Mensink R, Zock P, Kester A, Katan M . Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: a meta-analysis of 60 controlled trials. Am J Clin Nutr. 2003; 77(5):1146-55. DOI: 10.1093/ajcn/77.5.1146. View

Teng K, Nagapan G, Cheng H, Nesaretnam K . Palm olein and olive oil cause a higher increase in postprandial lipemia compared with lard but had no effect on plasma glucose, insulin and adipocytokines. Lipids. 2011; 46(4):381-8. DOI: 10.1007/s11745-010-3516-y. View

Sanders T, Filippou A, Berry S, Baumgartner S, Mensink R . Palmitic acid in the sn-2 position of triacylglycerols acutely influences postprandial lipid metabolism. Am J Clin Nutr. 2011; 94(6):1433-41. DOI: 10.3945/ajcn.111.017459. View

Meng H, Matthan N, Wu D, Li L, Rodriguez-Morato J, Cohen R . Comparison of diets enriched in stearic, oleic, and palmitic acids on inflammation, immune response, cardiometabolic risk factors, and fecal bile acid concentrations in mildly hypercholesterolemic postmenopausal women-randomized crossover trial. Am J Clin Nutr. 2019; 110(2):305-315. DOI: 10.1093/ajcn/nqz095. View

Filippou A, Berry S, Baumgartner S, Mensink R, Sanders T . Palmitic acid in the sn-2 position decreases glucose-dependent insulinotropic polypeptide secretion in healthy adults. Eur J Clin Nutr. 2014; 68(5):549-54. DOI: 10.1038/ejcn.2014.49. View

Evans K, Kuusela P, Cruz M, Wilhelmova I, Fielding B, Frayn K . Rapid chylomicron appearance following sequential meals: effects of second meal composition. Br J Nutr. 1998; 79(5):425-9. DOI: 10.1079/bjn19980072. View

Silva K, Wright J, Williams C, Lovegrove J . Meal ingestion provokes entry of lipoproteins containing fat from the previous meal: possible metabolic implications. Eur J Nutr. 2004; 44(6):377-83. DOI: 10.1007/s00394-004-0538-3. View

10.

van Rooijen M, Plat J, Blom W, Zock P, Mensink R . Dietary stearic acid and palmitic acid do not differently affect ABCA1-mediated cholesterol efflux capacity in healthy men and postmenopausal women: A randomized controlled trial. Clin Nutr. 2020; 40(3):804-811. DOI: 10.1016/j.clnu.2020.08.016. View

11.

Dubois C, Beaumier G, Juhel C, Armand M, PORTUGAL H, PAULI A . Effects of graded amounts (0-50 g) of dietary fat on postprandial lipemia and lipoproteins in normolipidemic adults. Am J Clin Nutr. 1998; 67(1):31-8. DOI: 10.1093/ajcn/67.1.31. View

12.

Matthews J, Altman D, Campbell M, Royston P . Analysis of serial measurements in medical research. BMJ. 1990; 300(6719):230-5. PMC: 1662068. DOI: 10.1136/bmj.300.6719.230. View

13.

Berry S . Triacylglycerol structure and interesterification of palmitic and stearic acid-rich fats: an overview and implications for cardiovascular disease. Nutr Res Rev. 2009; 22(1):3-17. DOI: 10.1017/S0954422409369267. View

14.

Baumgartner S, Mensink R, Plat J . Effects of a Plant Sterol or Stanol Enriched Mixed Meal on Postprandial Lipid Metabolism in Healthy Subjects. PLoS One. 2016; 11(9):e0160396. PMC: 5017646. DOI: 10.1371/journal.pone.0160396. View

15.

Tushuizen M, Nieuwland R, Scheffer P, Sturk A, Heine R, Diamant M . Two consecutive high-fat meals affect endothelial-dependent vasodilation, oxidative stress and cellular microparticles in healthy men. J Thromb Haemost. 2006; 4(5):1003-10. DOI: 10.1111/j.1538-7836.2006.01914.x. View

16.

Jackson K, Wolstencroft E, Bateman P, Yaqoob P, Williams C . Acute effects of meal fatty acids on postprandial NEFA, glucose and apo E response: implications for insulin sensitivity and lipoprotein regulation?. Br J Nutr. 2005; 93(5):693-700. DOI: 10.1079/bjn20051410. View