Rab26 Suppresses Migration and Invasion of Breast Cancer Cells Through Mediating Autophagic Degradation of Phosphorylated Src

Overview

Journal Cell Death Dis

Specialties Cell Biology
General Medicine

Date 2021 Mar 18

PMID 33731709

Citations 15

Authors

Huiying Liu

Yuxia Zhou

Hantian Qiu

Ruijuan Zhuang

Yang Han

Xiaoqing Liu

Xi Qiu

Ziyan Wang

Liju Xu

Ran Tan

Wanjin Hong

Tuanlao Wang

Affiliations

Soon will be listed here.

Abstract

Rab proteins play crucial roles in membrane trafficking. Some Rab proteins are implicated in cancer development through regulating protein sorting or degradation. In this study, we found that the expression of Rab26 is suppressed in the aggressive breast cancer cells as compared to the levels in non-invasive breast cancer cells. Over-expression of Rab26 inhibits cell migration and invasion, while Rab26 knockdown significantly promotes the migration and invasion of breast cancer cells. Rab26 reduces focal adhesion association of Src kinase and induces endosomal translocation of Src. Further experiments revealed that Rab26 mediates the autophagic degradation of phosphorylated Src through interacting with ATG16L1, consequently, resulting in the suppression of the migration and invasion ability of breast cancer cells.

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