Minocycline Prevents Primary Duck Neurons from Duck Tembusu Virus-induced Death

Overview

Journal J Vet Med Sci

Specialty Veterinary Medicine

Date 2021 Mar 15

PMID 33716232

Citations 2

Authors

Sittinee Kulprasertsri

Keisuke Aoshima

Atsushi Kobayashi

Takashi Kimura

Affiliations

Soon will be listed here.

Abstract

Duck Tembusu virus (DTMUV), a neurotropic flavivirus, is a causative agent of severe neurological diseases in different birds. No approved vaccines or antiviral therapeutic treatments are available to date. The poultry industry experiences significant economic losses due to DTMUV infections. Minocycline is a second-generation semi-synthetic tetracycline analogue that is commonly used as an antimicrobial treatment. Experimental studies have indicated the successful protective effects of minocycline against neuronal cell death from neurodegenerative diseases and viral encephalitis. The aim of this study was to investigate the effects of minocycline on DTMUV infection in neurons. Primary duck neurons were treated with minocycline, which exhibited neuroprotective effects via anti-apoptotic function rather than through viral replication inhibition. Minocycline might serve as a potential effective drug in DTMUV infection.

Citing Articles

Minocycline Inhibits Tick-Borne Encephalitis Virus and Protects Infected Cells via Multiple Pathways.

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PMID: 39066217 PMC: 11281541. DOI: 10.3390/v16071055.

New Insights into the Biology of the Emerging Tembusu Virus.

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