Linc00641 Promotes the Progression of Gastric Carcinoma by Modulating the MiR-429/Notch-1 Axis

Overview

Journal Aging (Albany NY)

Specialty Geriatrics

Date 2021 Mar 13

PMID 33714199

Citations 6

Authors

Qun Hang

Jie Lu

Lugen Zuo

Mulin Liu

Affiliations

Soon will be listed here.

Abstract

Linc00641 plays different roles in various types of human cancers. However, the function of linc00641 and its underlying mechanism of action in gastric cancer have not been fully elucidated. Therefore, the aim of our current study was to explore the molecular mechanism of linc00641 in gastric cancer. MTT assays, flow cytometry, wound healing assays, and Transwell invasion assays were utilized to measure cell viability, apoptosis, migration and invasion, respectively. Western blotting and RT-PCR assays were carried out to explore the mechanism of linc00641 in gastric cancer cells. We found that silencing linc00641 suppressed the viability and stimulated the apoptosis of gastric cancer cells, while linc00641 overexpression had the opposite effects. Moreover, linc00641 sponged the expression of miR-429 and subsequently upregulated Notch-1 expression in gastric cancer cells. We concluded that linc00641 promoted the malignant progression of gastric cancer by modulating the miR-429/Notch-1 axis.

Citing Articles

The plasticity of epithelial cells and its potential in the induced differentiation of gastric cancer.

Yan Z, Liu Y, Yuan Y Cell Death Discov. 2024; 10(1):512.

PMID: 39719478 PMC: 11668900. DOI: 10.1038/s41420-024-02275-x.

The knockdown of lncRNA DLGAP1-AS2 suppresses osteosarcoma progression by inhibiting aerobic glycolysis via the miR-451a/HK2 axis.

Zheng C, Li R, Zheng S, Fang H, Xu M, Zhong L Cancer Sci. 2023; 114(12):4747-4762.

PMID: 37817462 PMC: 10728003. DOI: 10.1111/cas.15989.

The role of miR-200 family in the regulation of hallmarks of cancer.

Klicka K, Grzywa T, Mielniczuk A, Klinke A, Wlodarski P Front Oncol. 2022; 12:965231.

PMID: 36158660 PMC: 9492973. DOI: 10.3389/fonc.2022.965231.

Long Intergenic Noncoding RNA 00641 Promotes Growth and Invasion of Colorectal Cancer through Regulating miR-450b-5p/GOLPH3 Axis.

Hong Z, Pan J, Chen M, Deng X, Chen Z, Wang C J Oncol. 2022; 2022:8259135.

PMID: 35756081 PMC: 9217543. DOI: 10.1155/2022/8259135.

Identification of N6-Methyladenosine-Related lncRNAs as a Prognostic Signature in Glioma.

Chen Y, Guo Y, Li S, Xu J, Wang X, Ning W Front Oncol. 2022; 12:789283.

PMID: 35311131 PMC: 8927984. DOI: 10.3389/fonc.2022.789283.

References

Yao J, Qian C . Over-activated Notch-1 protects gastric carcinoma BGC-823 cells from TNFalpha-induced apoptosis. Dig Liver Dis. 2009; 41(12):867-74. DOI: 10.1016/j.dld.2009.03.013. View

Sun T, Wang C, Xing J, Wu D . miR-429 modulates the expression of c-myc in human gastric carcinoma cells. Eur J Cancer. 2011; 47(17):2552-9. DOI: 10.1016/j.ejca.2011.05.021. View

Ni J, Yang Y, Liu D, Sun H, Jin S, Li J . MicroRNA-429 inhibits gastric cancer migration and invasion through the downregulation of specificity protein 1. Oncol Lett. 2017; 13(5):3845-3849. PMC: 5431332. DOI: 10.3892/ol.2017.5869. View

Hu Y, Su Y, Lei X, Zhao H, Wang L, Xu T . LINC00641/miR-582-5p mediate oxaliplatin resistance by activating autophagy in gastric adenocarcinoma. Sci Rep. 2020; 10(1):14981. PMC: 7486928. DOI: 10.1038/s41598-020-70913-2. View

Zhu P, Zhang J, Zhu J, Shi J, Zhu Q, Gao Y . MiR-429 Induces Gastric Carcinoma Cell Apoptosis Through Bcl-2. Cell Physiol Biochem. 2015; 37(4):1572-80. DOI: 10.1159/000438524. View

Mao Q, Lv M, Li L, Sun Y, Liu S, Shen Y . Long intergenic noncoding RNA 00641 inhibits breast cancer cell proliferation, migration, and invasion by sponging miR-194-5p. J Cell Physiol. 2019; 235(3):2668-2675. DOI: 10.1002/jcp.29170. View

Sheng N, Zhang L, Yang S . MicroRNA-429 decreases the invasion ability of gastric cancer cell line BGC-823 by downregulating the expression of heparanase. Exp Ther Med. 2018; 15(2):1927-1933. PMC: 5776652. DOI: 10.3892/etm.2017.5608. View

Zhang Y, Yu R, Li L . LINC00641 hinders the progression of cervical cancer by targeting miR-378a-3p/CPEB3. J Gene Med. 2020; 22(9):e3212. DOI: 10.1002/jgm.3212. View

Tan H, Zhang S, Zhang J, Zhu L, Chen Y, Yang H . Long non-coding RNAs in gastric cancer: New emerging biological functions and therapeutic implications. Theranostics. 2020; 10(19):8880-8902. PMC: 7392009. DOI: 10.7150/thno.47548. View

10.

Wu X, Liu W, Tang D, Xiao H, Wu Z, Chen C . Prognostic values of four Notch receptor mRNA expression in gastric cancer. Sci Rep. 2016; 6:28044. PMC: 4929462. DOI: 10.1038/srep28044. View

11.

Hang Q, Sun R, Jiang C, Li Y . Notch 1 promotes cisplatin-resistant gastric cancer formation by upregulating lncRNA AK022798 expression. Anticancer Drugs. 2015; 26(6):632-40. DOI: 10.1097/CAD.0000000000000227. View

12.

Ulitsky I . Evolution to the rescue: using comparative genomics to understand long non-coding RNAs. Nat Rev Genet. 2016; 17(10):601-14. DOI: 10.1038/nrg.2016.85. View

13.

Zhang M, Dong B, Lu M, Zheng M, Chen H, Ding J . miR-429 functions as a tumor suppressor by targeting FSCN1 in gastric cancer cells. Onco Targets Ther. 2016; 9:1123-33. PMC: 4780435. DOI: 10.2147/OTT.S91879. View

14.

Chen Y, He J, Su C, Wang H, Chen Y, Guo W . LINC00461 affects the survival of patients with renal cell carcinoma by acting as a competing endogenous RNA for microRNA‑942. Oncol Rep. 2019; 42(5):1924-1934. PMC: 6775798. DOI: 10.3892/or.2019.7311. View

15.

Yang J, Yu D, Liu X, Changyong E, Yu S . LINC00641/miR-4262/NRGN axis confines cell proliferation in glioma. Cancer Biol Ther. 2020; 21(8):758-766. PMC: 7515501. DOI: 10.1080/15384047.2020.1776581. View

16.

Yao R, Wang Y, Chen L . Cellular functions of long noncoding RNAs. Nat Cell Biol. 2019; 21(5):542-551. DOI: 10.1038/s41556-019-0311-8. View

17.

Wang J, Liu Z, Yu L . Long non-coding RNA LINC00641 promotes cell growth and migration through modulating miR-378a/ZBTB20 axis in acute myeloid leukemia. Eur Rev Med Pharmacol Sci. 2019; 23(17):7498-7509. DOI: 10.26355/eurrev_201909_18864. View

18.

Zhang J, Wong C, Leung K, Wu F, Zhou Y, Tong J . FGF18-FGFR2 signaling triggers the activation of c-Jun-YAP1 axis to promote carcinogenesis in a subgroup of gastric cancer patients and indicates translational potential. Oncogene. 2020; 39(43):6647-6663. PMC: 7581496. DOI: 10.1038/s41388-020-01458-x. View

19.

Marin J, Perez-Silva L, Macias R, Asensio M, Peleteiro-Vigil A, Sanchez-Martin A . Molecular Bases of Mechanisms Accounting for Drug Resistance in Gastric Adenocarcinoma. Cancers (Basel). 2020; 12(8). PMC: 7463778. DOI: 10.3390/cancers12082116. View

20.

Gao Y, Wang J, Ren J, Guo M, Guo C, Ning S . Long noncoding RNAs in gastric cancer: From molecular dissection to clinical application. World J Gastroenterol. 2020; 26(24):3401-3412. PMC: 7327794. DOI: 10.3748/wjg.v26.i24.3401. View