Role of Long Non-Coding RNA LINC00641 in Cancer

Overview

Journal Front Oncol

Specialty Oncology

Date 2022 Feb 14

PMID 35155216

Authors

Xue Han

Shitai Zhang

Affiliations

Soon will be listed here.

Abstract

Long non-coding RNAs (lncRNAs) are non-protein coding RNAs with more than 200 nucleic acids in length. When lncRNAs are located in the nucleus, they regulate chromosome structure, participate in chromatin remodeling, and act as transcription regulators. When lncRNAs are exported to the cytoplasm, they regulate mRNA stability, regulate translation, and interfere with post-translational modification. In recent years, more and more evidences have shown that lncRNA can regulate the biological processes of tumor proliferation, apoptosis, invasion and metastasis, and can participate in a variety of tumor signaling pathways. Long-gene non-protein coding RNA641 (LINC00641), located on human chromosome 14q11.2, is differentially expressed in a variety of tumors and is related to overall survival and prognosis, etc. Interfering the expression of LINC00641 can lead to changes in tumor cell proliferation, invasion, metastasis, apoptosis and other biological behaviors. Therefore, LINC00641 is a promising new biomarker and potential clinical therapeutic target. In this review, the biological functions, related mechanisms and clinical significance of LINC00641 in many human cancers are described in detail.

Citing Articles

Construction of prognostic markers for gastric cancer and comprehensive analysis of pyroptosis-related long non-coding RNAs.

Wang Y, Li D, Xun J, Wu Y, Wang H World J Gastrointest Surg. 2024; 16(7):2281-2295.

PMID: 39087128 PMC: 11287702. DOI: 10.4240/wjgs.v16.i7.2281.

ANOS1 accelerates the progression of esophageal cancer identified by multi-omic approaches.

Zhu Z, Dong S, Qin S, Gu K, Zhou Y Am J Cancer Res. 2024; 14(5):2343-2370.

PMID: 38859828 PMC: 11162658. DOI: 10.62347/SPCP3536.

lncRNA Biomarkers of Glioblastoma Multiforme.

Pokorna M, Cerna M, Boussios S, Ovsepian S, OLeary V Biomedicines. 2024; 12(5).

PMID: 38790894 PMC: 11117901. DOI: 10.3390/biomedicines12050932.

Decreased SPTBN2 expression regulated by the ceRNA network is associated with poor prognosis and immune infiltration in low‑grade glioma.

Chen G, Zhang Y, Zheng S, Xu Y, Lin P, Shang-Guan H Exp Ther Med. 2023; 25(6):253.

PMID: 37153896 PMC: 10161196. DOI: 10.3892/etm.2023.11952.

The Diagnostic and Therapeutic Role of snoRNA and lincRNA in Bladder Cancer.

Wang H, Feng Y, Zheng X, Xu X Cancers (Basel). 2023; 15(4).

PMID: 36831352 PMC: 9954389. DOI: 10.3390/cancers15041007.

References

Yang F, Xiao Z, Zhang S . Knockdown of miR-194-5p inhibits cell proliferation, migration and invasion in breast cancer by regulating the Wnt/β-catenin signaling pathway. Int J Mol Med. 2018; 42(6):3355-3363. PMC: 6202083. DOI: 10.3892/ijmm.2018.3897. View

Zhou R, Zhang E, Sun Q, Ye Z, Liu J, Zhou D . Integrated analysis of lncRNA-miRNA-mRNA ceRNA network in squamous cell carcinoma of tongue. BMC Cancer. 2019; 19(1):779. PMC: 6686570. DOI: 10.1186/s12885-019-5983-8. View

Wang J, Zhou H, Tu X, He Y, Liu Q, Liu Q . Prediction of competing endogenous RNA coexpression network as prognostic markers in AML. Aging (Albany NY). 2019; 11(10):3333-3347. PMC: 6555472. DOI: 10.18632/aging.101985. View

Xue D, Xue Y, Zhang L, Cui L, Guo K, Lian J . LINC00641 induces the malignant progression of colorectal carcinoma through the miRNA-424-5p/PLSCR4 feedback loop. Eur Rev Med Pharmacol Sci. 2021; 25(2):749-757. DOI: 10.26355/eurrev_202101_24636. View

Stratton M, Campbell P, Futreal P . The cancer genome. Nature. 2009; 458(7239):719-24. PMC: 2821689. DOI: 10.1038/nature07943. View

Waldman A, Schmults C . Cutaneous Squamous Cell Carcinoma. Hematol Oncol Clin North Am. 2018; 33(1):1-12. DOI: 10.1016/j.hoc.2018.08.001. View

Wang Y, Sun B, Wen X, Hao D, Du D, He G . The Roles of lncRNA in Cutaneous Squamous Cell Carcinoma. Front Oncol. 2020; 10:158. PMC: 7059100. DOI: 10.3389/fonc.2020.00158. View

Fu C, Li D, Zhang X, Liu N, Chi G, Jin X . LncRNA PVT1 Facilitates Tumorigenesis and Progression of Glioma via Regulation of MiR-128-3p/GREM1 Axis and BMP Signaling Pathway. Neurotherapeutics. 2018; 15(4):1139-1157. PMC: 6277294. DOI: 10.1007/s13311-018-0649-9. View

Wang K, Chang H . Molecular mechanisms of long noncoding RNAs. Mol Cell. 2011; 43(6):904-14. PMC: 3199020. DOI: 10.1016/j.molcel.2011.08.018. View

10.

Lan Y, Xiao X, He Z, Luo Y, Wu C, Li L . Long noncoding RNA OCC-1 suppresses cell growth through destabilizing HuR protein in colorectal cancer. Nucleic Acids Res. 2018; 46(11):5809-5821. PMC: 6009600. DOI: 10.1093/nar/gky214. View

11.

Prada-Arismendy J, Arroyave J, Rothlisberger S . Molecular biomarkers in acute myeloid leukemia. Blood Rev. 2016; 31(1):63-76. DOI: 10.1016/j.blre.2016.08.005. View

12.

Kretschmer A, Tilki D . Biomarkers in prostate cancer - Current clinical utility and future perspectives. Crit Rev Oncol Hematol. 2017; 120:180-193. DOI: 10.1016/j.critrevonc.2017.11.007. View

13.

Wang H, Huo X, Yang X, He J, Cheng L, Wang N . STAT3-mediated upregulation of lncRNA HOXD-AS1 as a ceRNA facilitates liver cancer metastasis by regulating SOX4. Mol Cancer. 2017; 16(1):136. PMC: 5558651. DOI: 10.1186/s12943-017-0680-1. View

14.

Brody H . Colorectal cancer. Nature. 2015; 521(7551):S1. DOI: 10.1038/521S1a. View

15.

Xie Y, Dang W, Zhang S, Yue W, Yang L, Zhai X . The role of exosomal noncoding RNAs in cancer. Mol Cancer. 2019; 18(1):37. PMC: 6408816. DOI: 10.1186/s12943-019-0984-4. View

16.

Dykes I, Emanueli C . Transcriptional and Post-transcriptional Gene Regulation by Long Non-coding RNA. Genomics Proteomics Bioinformatics. 2017; 15(3):177-186. PMC: 5487525. DOI: 10.1016/j.gpb.2016.12.005. View

17.

Dawson M, Kouzarides T . Cancer epigenetics: from mechanism to therapy. Cell. 2012; 150(1):12-27. DOI: 10.1016/j.cell.2012.06.013. View

18.

Gusyatiner O, Hegi M . Glioma epigenetics: From subclassification to novel treatment options. Semin Cancer Biol. 2017; 51:50-58. DOI: 10.1016/j.semcancer.2017.11.010. View

19.

Pavlova N, Thompson C . The Emerging Hallmarks of Cancer Metabolism. Cell Metab. 2016; 23(1):27-47. PMC: 4715268. DOI: 10.1016/j.cmet.2015.12.006. View

20.

Wei J, Huang K, Yang C, Kang C . Non-coding RNAs as regulators in epigenetics (Review). Oncol Rep. 2016; 37(1):3-9. DOI: 10.3892/or.2016.5236. View