Hypoxia Active Platinum(IV) Prodrugs of Orotic Acid Selective to Liver Cancer Cells

Overview

Journal Inorg Chem

Specialty Chemistry

Date 2021 Mar 12

PMID 33711231

Citations 2

Authors

Moumita Maji

Indira Bhattacharya

Sourav Acharya

Manas Pratim Chakraborty

Arnab Gupta

Arindam Mukherjee

Affiliations

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Abstract

Platinum(IV) complexes of orotic acid selectively target liver cancer cells displaying enhanced activity and higher uptake in Hep G2. The comparatively higher expression of Organic Anion Transporter 2 (OAT2) in Hep G2 and decrease in toxicity in the presence of OAT2 inhibitor suggest its involvement in the uptake of the complexes. They are resistant to sequestration by the copper transporter ATP7B, unlike cisplatin and oxaliplatin.

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