The Association Between Serum Testosterone Levels and Metabolic Syndrome Among Women

Overview

Journal Diabetol Metab Syndr

Publisher Biomed Central

Specialty Endocrinology

Date 2021 Mar 7

PMID 33676567

Citations 8

Authors

Junxiao Liang

Qiaohua Peng

Xinyun Yang

Chunbo Yang

Affiliations

Soon will be listed here.

Abstract

Background: This study aimed to investigate the relationship between total serum testosterone level (TT) and metabolic syndrome (MetS) among adult female population. Subgroup analysis further stratified the population by menopausal status to address the potential hormonal difference in postmenopausal women.

Methods: A total of 1966 participants from the National Health and Nutrition Examination Survey (NHANES) 2011-2012 cycle was included for analysis in this study. MetS was defined based on the National Cholesterol Education Program Adult Treatment Panel III guidelines. Serum TT was collected during the physical examination of the NHANES program and divided into quartiles (Q) in this analysis. Menopausal status was determined based on NHANES Reproductive Health Questionnaire. Logistic regression models were applied for analysis.

Results: The odds of MetS in Q2: 12.99-19.38 ng/mL (OR = 0.641, 95%CI 0.493-0.835, P < 0.01), Q3: 19.39-28.38 ng/mL (OR = 0.476, 95%CI 0.362-0.626, P < 0.001), and Q4: ≥28.40 ng/mL (OR = 0.390, 95%CI 0.294-0.517, P < 0.001) were statistically lower compared to the reference Q1: <12.99 ng/mL. For the postmenopausal group, a significantly lower odds of MetS was observed in the Q2 (OR = 0.689, 95%CI 0.486-0.977, P < 0.05) and Q4 (OR = 0.606, 95%CI 0.399-0.922, P < 0.05), while the odds of Q3 (OR = 0.439, 95%CI 0.248-0.779, P < 0.01) and Q4 (OR = 0.464, 95%CI 0.261-0.825, P < 0.01) were significantly lower than the reference Q1 in the premenopausal group.

Conclusions: Elevated TT levels are associated with incremental reductions in the odds of metabolic syndrome among adult females. Although, serum testosterone level is associated with the occurrence of metabolic syndrome in both the postmenopausal and the premenopausal group, the patterns of the relationship are different.

Citing Articles

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Kim K, Lee J, Kim S, Yu B, Kang J Korean J Fam Med. 2024; 45(4):215-222.

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Percent body fat was negatively correlated with Testosterone levels in male.

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References

Joyner M, Wallin B, Charkoudian N . Sex differences and blood pressure regulation in humans. Exp Physiol. 2015; 101(3):349-55. DOI: 10.1113/EP085146. View

Bellastella G, Menafra D, Puliani G, Colao A, Savastano S . How much does obesity affect the male reproductive function?. Int J Obes Suppl. 2019; 9(1):50-64. PMC: 6683183. DOI: 10.1038/s41367-019-0008-2. View

Brand J, Rovers M, Yeap B, Schneider H, Tuomainen T, Haring R . Testosterone, sex hormone-binding globulin and the metabolic syndrome in men: an individual participant data meta-analysis of observational studies. PLoS One. 2014; 9(7):e100409. PMC: 4096400. DOI: 10.1371/journal.pone.0100409. View

Schock H, Zeleniuch-Jacquotte A, Lundin E, Grankvist K, Lakso H, Idahl A . Hormone concentrations throughout uncomplicated pregnancies: a longitudinal study. BMC Pregnancy Childbirth. 2016; 16(1):146. PMC: 4932669. DOI: 10.1186/s12884-016-0937-5. View

Iranmanesh A, Lawson D, Veldhuis J . Glucose ingestion acutely lowers pulsatile LH and basal testosterone secretion in men. Am J Physiol Endocrinol Metab. 2012; 302(6):E724-30. PMC: 3311294. DOI: 10.1152/ajpendo.00520.2011. View

Patel S, Ratcliffe S, Reilly M, Weinstein R, Bhasin S, Blackman M . Higher serum testosterone concentration in older women is associated with insulin resistance, metabolic syndrome, and cardiovascular disease. J Clin Endocrinol Metab. 2009; 94(12):4776-84. PMC: 2795656. DOI: 10.1210/jc.2009-0740. View

Grundy S, Cleeman J, Daniels S, Donato K, Eckel R, Franklin B . Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation. 2005; 112(17):2735-52. DOI: 10.1161/CIRCULATIONAHA.105.169404. View

Laaksonen D, Niskanen L, Punnonen K, Nyyssonen K, Tuomainen T, Valkonen V . Testosterone and sex hormone-binding globulin predict the metabolic syndrome and diabetes in middle-aged men. Diabetes Care. 2004; 27(5):1036-41. DOI: 10.2337/diacare.27.5.1036. View

Muller M, Grobbee D, Tonkelaar I, Lamberts S, van der Schouw Y . Endogenous sex hormones and metabolic syndrome in aging men. J Clin Endocrinol Metab. 2005; 90(5):2618-23. DOI: 10.1210/jc.2004-1158. View

10.

Patni R, Mahajan A . The Metabolic Syndrome and Menopause. J Midlife Health. 2018; 9(3):111-112. PMC: 6166423. DOI: 10.4103/0976-7800.241951. View

11.

Rodriguez A, Muller D, Metter E, Maggio M, Harman S, Blackman M . Aging, androgens, and the metabolic syndrome in a longitudinal study of aging. J Clin Endocrinol Metab. 2007; 92(9):3568-72. DOI: 10.1210/jc.2006-2764. View

12.

Laaksonen D, Niskanen L, Punnonen K, Nyyssonen K, Tuomainen T, Salonen R . Sex hormones, inflammation and the metabolic syndrome: a population-based study. Eur J Endocrinol. 2003; 149(6):601-8. DOI: 10.1530/eje.0.1490601. View

13.

Janssen I, Powell L, Crawford S, Lasley B, Sutton-Tyrrell K . Menopause and the metabolic syndrome: the Study of Women's Health Across the Nation. Arch Intern Med. 2008; 168(14):1568-75. PMC: 2894539. DOI: 10.1001/archinte.168.14.1568. View

14.

Goldman A, Bhasin S, Wu F, Krishna M, Matsumoto A, Jasuja R . A Reappraisal of Testosterone's Binding in Circulation: Physiological and Clinical Implications. Endocr Rev. 2017; 38(4):302-324. PMC: 6287254. DOI: 10.1210/er.2017-00025. View

15.

Barthelmess E, Naz R . Polycystic ovary syndrome: current status and future perspective. Front Biosci (Elite Ed). 2014; 6(1):104-19. PMC: 4341818. DOI: 10.2741/e695. View

16.

Kim M, Kyung Y, Ahn T . Cross-Sectional Association of Metabolic Syndrome and Its Components with Serum Testosterone Levels in a Korean-Screened Population. World J Mens Health. 2019; 38(1):85-94. PMC: 6920064. DOI: 10.5534/wjmh.190030. View

17.

Teixeira H, Barbosa E, Souto P, Mariante A, Ramos A . Postpartum hormone and energy profiles and their influence on the resumption of ovarian cyclicity in Curraleiro Pé-Duro cows. Theriogenology. 2017; 95:133-140. DOI: 10.1016/j.theriogenology.2017.03.013. View

18.

Sarrel P . Androgen deficiency: menopause and estrogen-related factors. Fertil Steril. 2002; 77 Suppl 4:S63-7. DOI: 10.1016/s0015-0282(02)02967-9. View

19.

Ziaei S, Mohseni H . Correlation between Hormonal Statuses and Metabolic Syndrome in Postmenopausal Women. J Family Reprod Health. 2014; 7(2):63-6. PMC: 4064771. View

20.

Traish A, Haider A, Doros G, Saad F . Long-term testosterone therapy in hypogonadal men ameliorates elements of the metabolic syndrome: an observational, long-term registry study. Int J Clin Pract. 2013; 68(3):314-29. PMC: 4282282. DOI: 10.1111/ijcp.12319. View