BLEND-A: Blending Internet Treatment into Conventional Face-to-face Treatment for Alcohol Use Disorder - a Study Protocol

Overview

Journal BMC Psychiatry

Publisher Biomed Central

Specialty Psychiatry

Date 2021 Mar 7

PMID 33676429

Citations 5

Authors

Angelina Isabella Mellentin

Silke Behrendt

Randi Bilberg

Matthijs Blankers

Marie Paldam Folker

Kristine Tarp

Jakob Uffelmann

Anette Sogaard Nielsen

Affiliations

Soon will be listed here.

Abstract

Background: A major challenge to psychological treatment for alcohol use disorder (AUD) is patient non-compliance. A promising new treatment approach that is hypothesized to increase patient compliance is blended treatment, consisting of face-to-face contact with a therapist combined with modules delivered over the internet within the same protocol. While this treatment concept has been developed and proven effective for a variety of mental disorders, it has not yet been examined for AUD.

Aims: The study described in this protocol aims to examine and evaluate patient compliance with blended AUD treatment as well as the clinical and cost effectiveness of such treatment compared to face-to-face treatment only.

Methods: The study design is a pragmatic, stepped-wedge cluster randomized controlled trial. The included outpatient institutions (planned number of patients: n = 1800) will be randomized in clusters to implement either blended AUD treatment or face-to-face treatment only, i.e. treatment as usual (TAU). Both treatment approaches consist of motivational interviewing and cognitive behavioral therapy. Data on sociodemographics, treatment (e.g. intensity, duration), type of treatment conclusion (compliance vs. dropout), alcohol consumption, addiction severity, consequences of drinking, and quality of life, will be collected at treatment entry, at treatment conclusion, and 6 months after treatment conclusion. The primary outcome is compliance at treatment conclusion, and the secondary outcomes include alcohol consumption and quality of life at six-months follow-up. Data will be analyzed with an Intention-to-treat approach by means of generalized linear mixed models with a random effect for cluster and fixed effect for each step. Also, analyses evaluating cost-effectiveness will be conducted.

Discussion: Blended treatment may increase treatment compliance and thus improve treatment outcomes due to increased flexibility of the treatment course. Since this study is conducted within an implementation framework it can easily be scaled up, and when successful, blended treatment has the potential to become an alternative offer in many outpatient clinics nationwide and internationally.

Trial Registration: Clinicaltrials.gov .: NCT04535258 , retrospectively registered 01.09.20.

Citing Articles

A qualitative study of the implementation and organization of the national Greenlandic addiction treatment service.

Flyger J, Larsen C, Jensen E, Niclasen B, Nielsen A Front Health Serv. 2024; 4:1219787.

PMID: 38510066 PMC: 10950955. DOI: 10.3389/frhs.2024.1219787.

Nonuse of Blended Web-Based and Face-To-Face Cognitive Behavioral Therapy for Alcohol Use Disorder: Qualitative Study.

Tarp K, Christiansen R, Bilberg R, Borkner S, Dalsgaard C, Paldam Folker M JMIR Form Res. 2024; 8:e45471.

PMID: 38349711 PMC: 10900073. DOI: 10.2196/45471.

Problematic substance use among patients in a Swedish outpatient psychiatry setting: staff and manager perceptions of digital options for increased intervention access.

Petersen E, Augustsson H, Berman A Addict Sci Clin Pract. 2023; 18(1):65.

PMID: 37875999 PMC: 10594773. DOI: 10.1186/s13722-023-00421-x.

Perceived barriers to seeking treatment for alcohol use disorders among the general Danish population - a cross sectional study on the role of severity of alcohol use and gender.

Wallhed Finn S, Mejldal A, Nielsen A Arch Public Health. 2023; 81(1):65.

PMID: 37087483 PMC: 10122805. DOI: 10.1186/s13690-023-01085-4.

Blended Treatment for Alcohol Use Disorder (Blend-A): Explorative Mixed Methods Pilot and Feasibility Study.

Tarp K, Rasmussen J, Mejldal A, Paldam Folker M, Nielsen A JMIR Form Res. 2022; 6(4):e17761.

PMID: 35468082 PMC: 9086873. DOI: 10.2196/17761.

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