High-flow Therapy: Physiological Effects and Clinical Applications

Overview

Journal Breathe (Sheff)

Specialty Pulmonary Medicine

Date 2021 Mar 5

PMID 33664838

Citations 21

Authors

Rebecca F DCruz

Nicholas Hart

Georgios Kaltsakas

Affiliations

Soon will be listed here.

Abstract

Educational Aims: Provide a practical guide to HFT setup and delivery.Outline the physiological effects of HFT on the respiratory system.Describe clinical applications of HFT in adult respiratory and critical care medicine and evaluate the supporting evidence.Discuss application of HFT in COVID-19 and aerosolisation of respiratory droplets.

Citing Articles

Comparison of high-flow nasal oxygen therapy and noninvasive ventilation in suspected sepsis patients with acute respiratory distress in the emergency department: a retrospective cohort study.

Angkoontassaneeyarat C, Charoenphon P, Sanguanwit P, Yuksen C, Seesuklom S Int J Emerg Med. 2025; 18(1):52.

PMID: 40065238 PMC: 11895199. DOI: 10.1186/s12245-025-00842-2.

Home high-flow therapy during recovery from severe chronic obstructive pulmonary disease (COPD) exacerbation: a mixed-methods feasibility randomised control trial.

DCruz R, Rossel A, Kaltsakas G, Suh E, Douiri A, Rose L BMJ Open Respir Res. 2025; 12(1).

PMID: 39762067 PMC: 11784159. DOI: 10.1136/bmjresp-2024-002698.

Predictors of high-flow nasal cannula (HFNC) failure in severe community-acquired pneumonia or COVID-19.

Grunewaldt A, Gaillard M, Rohde G Intern Emerg Med. 2024; .

PMID: 39733203 DOI: 10.1007/s11739-024-03844-9.

New Frontiers in High-Flow Therapy.

Gonzalez Ramos L, Sayas Catalan J, Villena Garrido V Open Respir Arch. 2024; 6(4):100355.

PMID: 39493367 PMC: 11528228. DOI: 10.1016/j.opresp.2024.100355.

High-flow nasal cannula in adults with chronic respiratory diseases during physical exercise: a systematic review and meta-analysis.

Moya-Gallardo E, Fajardo-Gutierrez J, Acevedo K, Verdugo-Paiva F, Bravo-Jeria R, Ortiz-Munoz L BMJ Open Respir Res. 2024; 11(1).

PMID: 39438081 PMC: 11499805. DOI: 10.1136/bmjresp-2024-002431.

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