Susceptibility and Resistance in Leprosy: Studies in the Mouse Model

Overview

Journal Immunol Rev

Specialties Allergy & Immunology
General Surgery

Date 2021 Mar 4

PMID 33660297

Citations 9

Authors

Linda B Adams

Affiliations

Soon will be listed here.

Abstract

Leprosy is a chronic granulomatous infectious disease caused by the pathogen, Mycobacterium leprae, and the more recently discovered, M. lepromatosis. Described in 1873, M. leprae was among the first microorganisms to be proposed as a cause of a human infectious disease. As an obligate intracellular bacterium, it has still not thus far been reproducibly cultivated in axenic medium or cell cultures. Shepard's mouse footpad assay, therefore, was truly a breakthrough in leprosy research. The generation of immunosuppressed and genetically engineered mice, along with advances in molecular and cellular techniques, has since offered more tools for the study of the M. leprae-induced granuloma. While far from perfect, these new mouse models have provided insights into the immunoregulatory mechanisms responsible for the spectrum of this complex disease.

Citing Articles

Leprosy.

Grijsen M, Nguyen T, Pinheiro R, Singh P, Lambert S, Walker S Nat Rev Dis Primers. 2024; 10(1):90.

PMID: 39609422 DOI: 10.1038/s41572-024-00575-1.

Human Skin as an Ex Vivo Model for Maintaining and Leprosy Studies.

de Paula N, Leite M, Bertoluci D, Soares C, Rosa P, Cipriani Frade M Trop Med Infect Dis. 2024; 9(6).

PMID: 38922047 PMC: 11209558. DOI: 10.3390/tropicalmed9060135.

Qua vadis leprosy?.

Daniel E, Ebenezer G Indian J Med Res. 2023; 157(1):5-10.

PMID: 37040221 PMC: 10284368. DOI: 10.4103/ijmr.ijmr_2641_22.

Activated TLR2/4-positive T cells boost cell exhaustion during lepromatous leprosy infection via PD-1 upregulation.

Sadhu S, Kumar S, Mitra D, Joshi B Heliyon. 2022; 8(11):e11633.

PMID: 36419668 PMC: 9676533. DOI: 10.1016/j.heliyon.2022.e11633.

Pathogenicity and virulence of .

Sugawara-Mikami M, Tanigawa K, Kawashima A, Kiriya M, Nakamura Y, Fujiwara Y Virulence. 2022; 13(1):1985-2011.

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