Is It Reasonable to Ignore Vitamin D Status for Musculoskeletal Health?

Overview

Journal Fac Rev

Specialty Biomedical Engineering

Date 2021 Mar 4

PMID 33659951

Citations 2

Authors

Rebecca S Mason

Mark S Rybchyn

Tara C Brennan-Speranza

David R Fraser

Affiliations

Soon will be listed here.

Abstract

Severe vitamin D deficiency-25-hydroxyvitamin D (25OHD) concentrations below around 25-30 nmol/L-may lead to growth plate disorganization and mineralization abnormalities in children (rickets) and mineralization defects throughout the skeleton (osteomalacia) and proximal muscle weakness. Both problems are reversed with vitamin D treatment. Apart from this musculoskeletal dysfunction at very low vitamin D levels, there is apparent inconsistency in the available data about whether concentrations of 25OHD below around 50 nmol/L cause muscle function impairment and increase the risk of fracture. This narrative review provides evidence to support the contention that improving vitamin D status, up to around 50 nmol/L, plays a small causal role in optimizing bone and muscle function as well as reducing overall mortality.

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