Prognostic Significance of the Immunological Indices in Patients Who Underwent Complete Resection of Pulmonary Metastases of Colorectal Cancer

Overview

Journal In Vivo

Specialty Oncology

Date 2021 Feb 24

PMID 33622906

Citations 6

Authors

Yuki Okazaki

Masatsune Shibutani

E N Wang

Hisashi Nagahara

Tatsunari Fukuoka

Yasuhito Iseki

Shinichiro Kashiwagi

Hiroaki Tanaka

Kiyoshi Maeda

Kosei Hirakawa

Masaichi Ohira

Affiliations

Soon will be listed here.

Abstract

Background/aim: The neutrophil-to-lymphocyte ratio (NLR) and the density of tumor-infiltrating lymphocytes (TILs) have been reported as immunological prognostic factors for various cancers. We evaluated the association between the prognosis and the immunological status in patients who underwent complete resection of pulmonary metastases of colorectal cancer (CRC).

Patients And Methods: We evaluated the associations between the NLR before the resection of pulmonary metastases and the relapse-free survival (RFS) or overall survival (OS), or between the density of TILs in the pulmonary metastasis and the RFS or OS.

Results: The RFS and OS were significantly worse in the NLR-High group than in the NLR-Low group. The RFS was significantly longer in the CD3TILs-High group than in the CD3TILs-Low group.

Conclusion: The NLR and the density of TILs may have prognostic significance in patients who undergo complete resection of pulmonary metastases of CRC.

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