» Articles » PMID: 33619875

Major Pathological Response After Neoadjuvant Immunotherapy in Esophageal Spindle Cell Carcinoma: A Case Report

Overview
Journal Thorac Cancer
Date 2021 Feb 23
PMID 33619875
Citations 2
Authors
Affiliations
Soon will be listed here.
Abstract

Esophageal spindle cell carcinoma (ESpCC) is a rare subtype of esophageal carcinoma, accounting for 1% of all esophageal malignancies. The clinical outcome is unknown due to the lack of treatment options. Here, we present the case of a 60-year-old male with initially unresectable ESpCC, in which platinum-based concurrent chemoradiotherapy was unsuccessful. He was subsequently treated with neoadjuvant immunotherapy and after surgery achieved a complete pathological response; therefore, neoadjuvant immunotherapy might be a novel option for ESpCC patients.

Citing Articles

Primary maxillary sinus carcinosarcoma with multidisciplinary management: a case report with 4 years follow-up and literature review.

Li J, Wang S, Tang X, Que L, Han W, Yu B BMC Oral Health. 2023; 23(1):96.

PMID: 36788533 PMC: 9926723. DOI: 10.1186/s12903-022-02604-5.


Major pathological response after neoadjuvant immunotherapy in esophageal spindle cell carcinoma: A case report.

Fu Y, Wang P, He D, Zheng Y, Ding Z Thorac Cancer. 2021; 12(8):1234-1239.

PMID: 33619875 PMC: 8046125. DOI: 10.1111/1759-7714.13905.

References
1.
Guarino M, Tricomi P, Giordano F, Cristofori E . Sarcomatoid carcinomas: pathological and histopathogenetic considerations. Pathology. 1996; 28(4):298-305. DOI: 10.1080/00313029600169224. View

2.
Sanada Y, Hihara J, Yoshida K, Yamaguchi Y . Esophageal carcinosarcoma with intramural metastasis. Dis Esophagus. 2006; 19(2):119-31. DOI: 10.1111/j.1442-2050.2006.00551.x. View

3.
Marabelle A, Fakih M, Lopez J, Shah M, Shapira-Frommer R, Nakagawa K . Association of tumour mutational burden with outcomes in patients with advanced solid tumours treated with pembrolizumab: prospective biomarker analysis of the multicohort, open-label, phase 2 KEYNOTE-158 study. Lancet Oncol. 2020; 21(10):1353-1365. DOI: 10.1016/S1470-2045(20)30445-9. View

4.
Kojima T, Shah M, Muro K, Francois E, Adenis A, Hsu C . Randomized Phase III KEYNOTE-181 Study of Pembrolizumab Versus Chemotherapy in Advanced Esophageal Cancer. J Clin Oncol. 2020; 38(35):4138-4148. DOI: 10.1200/JCO.20.01888. View

5.
Burmeister B, Smithers B, Gebski V, Fitzgerald L, Simes R, Devitt P . Surgery alone versus chemoradiotherapy followed by surgery for resectable cancer of the oesophagus: a randomised controlled phase III trial. Lancet Oncol. 2005; 6(9):659-68. DOI: 10.1016/S1470-2045(05)70288-6. View