Rapid Reduction of Macular Edema Due to Retinal Vein Occlusion with Low-dose Normobaric Hyperoxia

Overview

Journal Graefes Arch Clin Exp Ophthalmol

Specialty Ophthalmology

Date 2021 Feb 22

PMID 33616756

Citations 1

Authors

Jorge G Arroyo

Brendan Seto

Keiko Yamada

Ke Zeng

Robert Minturn

Colin A Lemire

Affiliations

Soon will be listed here.

Abstract

Purpose: We investigated the effects of a relatively inexpensive, non-invasive, short-term treatment with low-dose normobaric hyperoxia (NBH) on macular edema in patients with retinal vein occlusion (RVO).

Methods: Participants with macular edema associated with RVO were treated with 5 LPM of NBH via facemask (40% fraction of inspired oxygen, FIO2) for 3 h. Patients with non-fovea involving edema who elected to be observed returned for a second treatment 1 month later to test reproducibility.

Results: A 3-h session of NBH (n = 45) resulted in decreased maximum macular thickness (MMT) (mean 7.10%, t=9.63 P<.001) and central macular thickness (CMT) (mean 4.64%, t=6.90, P<.001) when compared to untreated eyes with RVO measured over the same period of time (n = 12) or their healthy fellow eye (n = 34; MMT:t=-9.60, P<.001;CMT: t=-6.72, P<.001). Patients who had a second NBH treatment 1 month later experienced a recurrence of their edema, but demonstrated a similar significant reduction in MMT and CMT after the second NBH treatment.

Conclusions: Three-hour treatment with 40% FIO2 NBH results in a significant reduction in MMT and CMT. This study supports an ischemic mechanism for macular edema associated with retinal vein occlusion.

Translational Relevance: Short-term low-dose normobaric hyperoxia is a simple, inexpensive, and ubiquitous treatment that may provide an alternate or adjunctive approach to treating macular edema in patients who are resistant to or cannot afford anti-VEGF medications.

Citing Articles

Effect of FFP2/N95 facemask wear on retinal and choroidal thickness profile in healthy subjects.

Gunay B, Akalin I, Kalkisim A, Esenulku C, Turkoglu E Int J Ophthalmol. 2022; 15(11):1821-1828.

PMID: 36404981 PMC: 9631179. DOI: 10.18240/ijo.2022.11.13.

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