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Retinal Oxygen: from Animals to Humans

Overview
Specialty Ophthalmology
Date 2017 Jan 23
PMID 28109737
Citations 111
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Abstract

This article discusses retinal oxygenation and retinal metabolism by focusing on measurements made with two of the principal methods used to study O in the retina: measurements of PO with oxygen-sensitive microelectrodes in vivo in animals with a retinal circulation similar to that of humans, and oximetry, which can be used non-invasively in both animals and humans to measure O concentration in retinal vessels. Microelectrodes uniquely have high spatial resolution, allowing the mapping of PO in detail, and when combined with mathematical models of diffusion and consumption, they provide information about retinal metabolism. Mathematical models, grounded in experiments, can also be used to simulate situations that are not amenable to experimental study. New methods of oximetry, particularly photoacoustic ophthalmoscopy and visible light optical coherence tomography, provide depth-resolved methods that can separate signals from blood vessels and surrounding tissues, and can be combined with blood flow measures to determine metabolic rate. We discuss the effects on retinal oxygenation of illumination, hypoxia and hyperoxia, and describe retinal oxygenation in diabetes, retinal detachment, arterial occlusion, and macular degeneration. We explain how the metabolic measurements obtained from microelectrodes and imaging are different, and how they need to be brought together in the future. Finally, we argue for revisiting the clinical use of hyperoxia in ophthalmology, particularly in retinal arterial occlusions and retinal detachment, based on animal research and diffusion theory.

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References
1.
Bhutto I, Lutty G . Understanding age-related macular degeneration (AMD): relationships between the photoreceptor/retinal pigment epithelium/Bruch's membrane/choriocapillaris complex. Mol Aspects Med. 2012; 33(4):295-317. PMC: 3392421. DOI: 10.1016/j.mam.2012.04.005. View

2.
Linsenmeier R, Yancey C . Effects of hyperoxia on the oxygen distribution in the intact cat retina. Invest Ophthalmol Vis Sci. 1989; 30(4):612-8. View

3.
Spaide R, Armstrong D, Browne R . Continuing medical education review: choroidal neovascularization in age-related macular degeneration--what is the cause?. Retina. 2003; 23(5):595-614. DOI: 10.1097/00006982-200310000-00001. View

4.
Niemeyer G, Nagahara K, DEMANT E . Effects of changes in arterial Po2 and Pco2 on the electroretinogram in the cat. Invest Ophthalmol Vis Sci. 1982; 23(5):678-83. View

5.
Aiello L, Avery R, Arrigg P, Keyt B, Jampel H, Shah S . Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N Engl J Med. 1994; 331(22):1480-7. DOI: 10.1056/NEJM199412013312203. View