Bi-enzymes Treatments Attenuate Cognitive Impairment Associated with Oxidative Damage of Heavy Metals

Overview

Journal R Soc Open Sci

Specialty Science

Date 2021 Feb 22

PMID 33614079

Citations 2

Authors

Chao Chen

Xiaoxin Zhang

Hao Huang

Hongyi Bao

Xiaodong Li

Ye Cheng

Jing Zhang

Yin Ding

Yanguang Yang

Haiying Gu

Donglin Xia

Affiliations

Soon will be listed here.

Abstract

Oxidative stress has been implicated in the pathogenesis of cognitive impairment. Lead (Pb) is a common environmental toxicant and plays a vital role in oxidative stress activation. In this study, a superoxide dismutase (SOD) and catalase (CAT) containing poly (lactic-co-glycolic acid) (PLGA) meso-particles (PLGA@SOD-CAT) were prepared to attenuate cognitive impairment via inhibiting oxidative stress in rats. It was prepared using a double emulsion (water/oil/water phase) technique to minimize the hazardous effects of Pb burden on cognitive impairment. The meso-particles antagonized the Pb-induced cognitive impairments. Behaviour, serum biochemical parameters and biomarkers of oxidative stress in rats were evaluated after they were subjected to intravenous injection with lead nitrate and PLGA@SOD-CAT. Moreover, the potential protective mechanism of PLGA@SOD-CAT was determined. Notably, PLGA@SOD-CAT appreciably agented memory impairment caused by lead nitrate and it could significantly inhibit Pb-induced oxidative stress in the blood. Furthermore, a remarkable reversion effect of cognitive impairments, including escape latency, crossing platform times and time per cent during the platform quadrant, after PLGA@SOD-CAT administration were noted. Therefore, these results suggested that the bi-enzymes platform was a superior product in eliminating Pb-induced cognitive impairments through reducing expression of Pb-associated oxidative stress, and it could potentially be applied in detoxifying heavy metals in blood circulation.

Citing Articles

Effects of Heavy Metal Exposure from Leather Processing Plants on Serum Oxidative Stress and the Milk Fatty Acid Composition of Dairy Cows: A Preliminary Study.

Su C, Qu X, Gao Y, Zhou X, Yang X, Zheng N Animals (Basel). 2022; 12(15).

PMID: 35892550 PMC: 9331539. DOI: 10.3390/ani12151900.

Bi-enzymes treatments attenuate cognitive impairment associated with oxidative damage of heavy metals.

Chen C, Zhang X, Huang H, Bao H, Li X, Cheng Y R Soc Open Sci. 2021; 8(1):201404.

PMID: 33614079 PMC: 7890482. DOI: 10.1098/rsos.201404.

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