Emerging Role of MicroRNAs in the Pathogenesis of Amyotrophic Lateral Sclerosis

Overview

Journal Metab Brain Dis

Publisher Springer

Specialties Endocrinology
Neurology

Date 2021 Feb 19

PMID 33604874

Citations 6

Authors

Nader Akbari Dilmaghani

Bashdar Mahmud Hussen

Saeedeh Nateghinia

Mohammad Taheri

Soudeh Ghafouri-Fard

Affiliations

Soon will be listed here.

Abstract

Amyotrophic lateral sclerosis (ALS) is a deadly motor neuron disease (MND) and the most frequent MND in adults. ALS is recognized by degenerative alterations in both upper and lower motor neurons. This disorder is classified to familial and sporadic classes. Disease-causing mutations in SOD1, C9ORF72, FUS, and TARDBP have been recognized in familial ALS cases. However, in spite of conduction of several genetic association studies, heritable genetic risk elements in sporadic have not been identified completely. Several miRNAs have been dysregulated in the serum samples or brain tissues of ALS patients. Moreover, a number of miRNAs have been suggested as putative biomarkers for sporadic ALS. In the current manuscript, we review of miRNAs in the development of ALS.

Citing Articles

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A Machine Learning Approach for Highlighting microRNAs as Biomarkers Linked to Amyotrophic Lateral Sclerosis Diagnosis and Progression.

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Liu J, Zhou F, Guan Y, Meng F, Zhao Z, Su Q Cells. 2022; 11(3).

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