Syntenin-knock out Reduces Exosome Turnover and Viral Transduction

Overview

Journal Sci Rep

Specialty Science

Date 2021 Feb 19

PMID 33602969

Citations 17

Authors

Rudra Kashyap

Marielle Balzano

Benoit Lechat

Kathleen Lambaerts

Antonio Luis Egea-Jimenez

Frederique Lembo

Joanna Fares

Sofie Meeussen

Sebastian Kugler

Anton Roebroek

Guido David

Pascale Zimmermann

Affiliations

Soon will be listed here.

Abstract

Exosomal transfers represent an important mode of intercellular communication. Syntenin is a small scaffold protein that, when binding ALIX, can direct endocytosed syndecans and syndecan cargo to budding endosomal membranes, supporting the formation of intraluminal vesicles that compose the source of a major class of exosomes. Syntenin, however, can also support the recycling of these same components to the cell surface. Here, by studying mice and cells with syntenin-knock out, we identify syntenin as part of dedicated machinery that integrates both the production and the uptake of secreted vesicles, supporting viral/exosomal exchanges. This study significantly extends the emerging role of heparan sulfate proteoglycans and syntenin as key components for macromolecular cargo internalization into cells.

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