Gene Deficiency Accelerates Unilateral Ureteral Obstruction-induced Kidney Inflammation Through Oxidative Stress and Activation of Macrophages

Overview

Journal Korean J Physiol Pharmacol

Specialty Pharmacology

Date 2021 Feb 19

PMID 33602884

Citations 4

Authors

Jee In Kim

Mi Ra Noh

Ga-Eun Yoon

Hee-Seong Jang

Min Jung Kong

Kwon Moo Park

Affiliations

Soon will be listed here.

Abstract

Mitochondrial NADP-dependent isocitrate dehydrogenase 2 () produces NADPH, which is known to inhibit mitochondrial oxidative stress. Ureteral obstruction induces kidney inflammation and fibrosis oxidative stress. Here, we investigated the role and underlying mechanism of in unilateral ureteral obstruction (UUO)-induced kidney inflammation using gene deleted mice (). Eight- to 10-week-old female mice and wild type () littermates were subjected to UUO and kidneys were harvested 5 days after UUO. was not detected in the kidneys of mice, while UUO decreased in mice. UUO increased the expressions of markers of oxidative stress in both and mice, and these changes were greater in mice compared to mice. Bone marrow-derived macrophages of mice showed a more migrating phenotype with greater ruffle formation and Rac1 distribution than that of mice. Correspondently, UUO-induced infiltration of monocytes/macrophages was greater in mice compared to mice. Taken together, these data demonstrate that plays a protective role against UUO-induced inflammation through inhibition of oxidative stress and macrophage infiltration.

Citing Articles

The role of murine M1 macrophages from different sources in unilateral ureteral obstruction.

Cui X, Hu Y, Zhang G, Zhao L, Ye T, Zhang Q Cent Eur J Immunol. 2023; 48(2):81-91.

PMID: 37692024 PMC: 10485685. DOI: 10.5114/ceji.2023.129975.

Sulforaphane Protects against Unilateral Ureteral Obstruction-Induced Renal Damage in Rats by Alleviating Mitochondrial and Lipid Metabolism Impairment.

Aranda-Rivera A, Cruz-Gregorio A, Aparicio-Trejo O, Tapia E, Sanchez-Lozada L, Garcia-Arroyo F Antioxidants (Basel). 2022; 11(10).

PMID: 36290577 PMC: 9598813. DOI: 10.3390/antiox11101854.

Involvement of Tricarboxylic Acid Cycle Metabolites in Kidney Diseases.

Jimenez-Uribe A, Hernandez-Cruz E, Ramirez-Magana K, Pedraza-Chaverri J Biomolecules. 2021; 11(9).

PMID: 34572472 PMC: 8465464. DOI: 10.3390/biom11091259.

Mitochondrial Redox Signaling and Oxidative Stress in Kidney Diseases.

Aranda-Rivera A, Cruz-Gregorio A, Aparicio-Trejo O, Pedraza-Chaverri J Biomolecules. 2021; 11(8).

PMID: 34439810 PMC: 8391472. DOI: 10.3390/biom11081144.

References

Jo S, Son M, Koh H, Lee S, Song I, Kim Y . Control of mitochondrial redox balance and cellular defense against oxidative damage by mitochondrial NADP+-dependent isocitrate dehydrogenase. J Biol Chem. 2001; 276(19):16168-76. DOI: 10.1074/jbc.M010120200. View

Sakai J, Li J, Subramanian K, Mondal S, Bajrami B, Hattori H . Reactive oxygen species-induced actin glutathionylation controls actin dynamics in neutrophils. Immunity. 2012; 37(6):1037-49. PMC: 3525814. DOI: 10.1016/j.immuni.2012.08.017. View

Noh M, Jang H, Song D, Lee S, Lipschutz J, Park K . Downregulation of exocyst Sec10 accelerates kidney tubule cell recovery through enhanced cell migration. Biochem Biophys Res Commun. 2018; 496(2):309-315. DOI: 10.1016/j.bbrc.2018.01.013. View

Harris I, Treloar A, Inoue S, Sasaki M, Gorrini C, Lee K . Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression. Cancer Cell. 2015; 27(2):211-22. DOI: 10.1016/j.ccell.2014.11.019. View

Han S, Jang H, Noh M, Kim J, Kong M, Kim J . Mitochondrial NADP-Dependent Isocitrate Dehydrogenase Deficiency Exacerbates Mitochondrial and Cell Damage after Kidney Ischemia-Reperfusion Injury. J Am Soc Nephrol. 2016; 28(4):1200-1215. PMC: 5373447. DOI: 10.1681/ASN.2016030349. View

Kim J, Noh M, Kim K, Jang H, Kim H, Park K . Methionine sulfoxide reductase A deficiency exacerbates progression of kidney fibrosis induced by unilateral ureteral obstruction. Free Radic Biol Med. 2015; 89:201-8. DOI: 10.1016/j.freeradbiomed.2015.07.018. View

Yeh C, Chiang H, Lai T, Chien C . Unilateral ureteral obstruction evokes renal tubular apoptosis via the enhanced oxidative stress and endoplasmic reticulum stress in the rat. Neurourol Urodyn. 2011; 30(3):472-9. DOI: 10.1002/nau.20855. View

Lee S, Cha H, Lee S, Kim H, Ku H, Kim S . Idh2 deficiency accelerates renal dysfunction in aged mice. Biochem Biophys Res Commun. 2017; 493(1):34-39. DOI: 10.1016/j.bbrc.2017.09.082. View

Eddy A . Interstitial macrophages as mediators of renal fibrosis. Exp Nephrol. 1995; 3(2):76-9. View

10.

Dendooven A, Ishola Jr D, Nguyen T, Van der Giezen D, Kok R, Goldschmeding R . Oxidative stress in obstructive nephropathy. Int J Exp Pathol. 2010; 92(3):202-10. PMC: 3101492. DOI: 10.1111/j.1365-2613.2010.00730.x. View

11.

Kong M, Han S, Kim J, Park J, Park K . Mitochondrial NADP-dependent isocitrate dehydrogenase deficiency increases cisplatin-induced oxidative damage in the kidney tubule cells. Cell Death Dis. 2018; 9(5):488. PMC: 5916920. DOI: 10.1038/s41419-018-0537-6. View

12.

Birben E, Sahiner U, Sackesen C, Erzurum S, Kalayci O . Oxidative stress and antioxidant defense. World Allergy Organ J. 2012; 5(1):9-19. PMC: 3488923. DOI: 10.1097/WOX.0b013e3182439613. View

13.

Sugiyama H, Kobayashi M, Wang D, Sunami R, Maeshima Y, Yamasaki Y . Telmisartan inhibits both oxidative stress and renal fibrosis after unilateral ureteral obstruction in acatalasemic mice. Nephrol Dial Transplant. 2005; 20(12):2670-80. DOI: 10.1093/ndt/gfi045. View

14.

Chevalier R, Thornhill B, Forbes M, Kiley S . Mechanisms of renal injury and progression of renal disease in congenital obstructive nephropathy. Pediatr Nephrol. 2009; 25(4):687-97. DOI: 10.1007/s00467-009-1316-5. View

15.

Han S, Choi H, Kim J, Park J, Park K . IDH2 deficiency increases the liver susceptibility to ischemia-reperfusion injury via increased mitochondrial oxidative injury. Redox Biol. 2017; 14:142-153. PMC: 5608561. DOI: 10.1016/j.redox.2017.09.003. View

16.

Rodriguez-Iturbe B, Vaziri N, Herrera-Acosta J, Johnson R . Oxidative stress, renal infiltration of immune cells, and salt-sensitive hypertension: all for one and one for all. Am J Physiol Renal Physiol. 2004; 286(4):F606-16. DOI: 10.1152/ajprenal.00269.2003. View

17.

Sacks S, Aparicio S, Bevan A, Oliver D, Will E, Davison A . Late renal failure due to prostatic outflow obstruction: a preventable disease. BMJ. 1989; 298(6667):156-9. PMC: 1835497. DOI: 10.1136/bmj.298.6667.156. View

18.

Reitman Z, Yan H . Isocitrate dehydrogenase 1 and 2 mutations in cancer: alterations at a crossroads of cellular metabolism. J Natl Cancer Inst. 2010; 102(13):932-41. PMC: 2897878. DOI: 10.1093/jnci/djq187. View

19.

Mari M, Morales A, Colell A, Garcia-Ruiz C, Fernandez-Checa J . Mitochondrial glutathione, a key survival antioxidant. Antioxid Redox Signal. 2009; 11(11):2685-700. PMC: 2821140. DOI: 10.1089/ARS.2009.2695. View

20.

Shin A, Kil I, Yang E, Huh T, Yang C, Park J . Regulation of high glucose-induced apoptosis by mitochondrial NADP+-dependent isocitrate dehydrogenase. Biochem Biophys Res Commun. 2004; 325(1):32-8. DOI: 10.1016/j.bbrc.2004.09.218. View