Oxidative Stress in Obstructive Nephropathy

Overview

Journal Int J Exp Pathol

Publisher Wiley

Specialty Pathology

Date 2010 Sep 1

PMID 20804541

Citations 60

Authors

Amelie Dendooven

David A Ishola Jr

Tri Q Nguyen

Dionne M Van der Giezen

Robbert Jan Kok

Roel Goldschmeding

Jaap A Joles

Affiliations

Soon will be listed here.

Abstract

Unilateral ureteric obstruction (UUO) is one of the most commonly applied rodent models to study the pathophysiology of renal fibrosis. This model reflects important aspects of inflammation and fibrosis that are prominent in human kidney diseases. In this review, we present an overview of the factors contributing to the pathophysiology of UUO, highlighting the role of oxidative stress.

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