The Protein Arginine Methyltransferase Family: an Update About Function, New Perspectives and the Physiological Role in Humans

Overview

Journal Cell Mol Life Sci

Publisher Springer

Specialty Biology

Date 2009 Mar 21

PMID 19300908

Citations 88

Authors

S S Wolf

Affiliations

Soon will be listed here.

Abstract

Information about the family of protein arginine methyltransferases (PRMTs) has been growing rapidly over the last few years and the emerging role of arginine methylation involved in cellular processes like signaling, RNA processing, gene transcription, and cellular transport function has been investigated. To date, 11 PRMTs gene transcripts have been identified in humans. Almost all PRMTs have been shown to have enzymatic activity and to catalyze arginine methylation. This review will summarize the overall function of human PRMTs and include novel highlights on each family member.

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References

Invernizzi C, Xie B, Frankel F, Feldhammer M, Roy B, Richard S . Arginine methylation of the HIV-1 nucleocapsid protein results in its diminished function. AIDS. 2007; 21(7):795-805. DOI: 10.1097/QAD.0b013e32803277ae. View

Hung C, Li C . Identification and phylogenetic analyses of the protein arginine methyltransferase gene family in fish and ascidians. Gene. 2004; 340(2):179-87. DOI: 10.1016/j.gene.2004.07.039. View

Sayegh J, Webb K, Cheng D, Bedford M, Clarke S . Regulation of protein arginine methyltransferase 8 (PRMT8) activity by its N-terminal domain. J Biol Chem. 2007; 282(50):36444-53. DOI: 10.1074/jbc.M704650200. View

Meister G, Fischer U . Assisted RNP assembly: SMN and PRMT5 complexes cooperate in the formation of spliceosomal UsnRNPs. EMBO J. 2002; 21(21):5853-63. PMC: 131082. DOI: 10.1093/emboj/cdf585. View

Fielenbach N, Guardavaccaro D, Neubert K, Chan T, Li D, Feng Q . DRE-1: an evolutionarily conserved F box protein that regulates C. elegans developmental age. Dev Cell. 2007; 12(3):443-55. DOI: 10.1016/j.devcel.2007.01.018. View

Verbiest V, Montaudon D, Tautu M, Moukarzel J, Portail J, Markovits J . Protein arginine (N)-methyl transferase 7 (PRMT7) as a potential target for the sensitization of tumor cells to camptothecins. FEBS Lett. 2008; 582(10):1483-9. DOI: 10.1016/j.febslet.2008.03.031. View

Bachand F . Protein arginine methyltransferases: from unicellular eukaryotes to humans. Eukaryot Cell. 2007; 6(6):889-98. PMC: 1951521. DOI: 10.1128/EC.00099-07. View

Pahlich S, Zakaryan R, Gehring H . Identification of proteins interacting with protein arginine methyltransferase 8: the Ewing sarcoma (EWS) protein binds independent of its methylation state. Proteins. 2008; 72(4):1125-37. DOI: 10.1002/prot.22004. View

Stallcup M, Chen D, Koh S, Ma H, Lee Y, Li H . Co-operation between protein-acetylating and protein-methylating co-activators in transcriptional activation. Biochem Soc Trans. 2000; 28(4):415-8. View

10.

Frietze S, Lupien M, Silver P, Brown M . CARM1 regulates estrogen-stimulated breast cancer growth through up-regulation of E2F1. Cancer Res. 2008; 68(1):301-6. DOI: 10.1158/0008-5472.CAN-07-1983. View

11.

Robin-Lespinasse Y, Sentis S, Kolytcheff C, Rostan M, Corbo L, Le Romancer M . hCAF1, a new regulator of PRMT1-dependent arginine methylation. J Cell Sci. 2007; 120(Pt 4):638-47. DOI: 10.1242/jcs.03357. View

12.

Chen D, Ma H, Hong H, Koh S, Huang S, Schurter B . Regulation of transcription by a protein methyltransferase. Science. 1999; 284(5423):2174-7. DOI: 10.1126/science.284.5423.2174. View

13.

Frankel A, Clarke S . PRMT3 is a distinct member of the protein arginine N-methyltransferase family. Conferral of substrate specificity by a zinc-finger domain. J Biol Chem. 2000; 275(42):32974-82. DOI: 10.1074/jbc.M006445200. View

14.

Zhang X, Cheng X . Structure of the predominant protein arginine methyltransferase PRMT1 and analysis of its binding to substrate peptides. Structure. 2003; 11(5):509-20. PMC: 4030380. DOI: 10.1016/s0969-2126(03)00071-6. View

15.

Le Poole I, Sarangarajan R, Zhao Y, Stennett L, Brown T, Sheth P . 'VIT1', a novel gene associated with vitiligo. Pigment Cell Res. 2002; 14(6):475-84. PMC: 1747534. DOI: 10.1034/j.1600-0749.2001.140608.x. View

16.

Ghosh S, Paik W, Kim S . Purification and molecular identification of two protein methylases I from calf brain. Myelin basic protein- and histone-specific enzyme. J Biol Chem. 1988; 263(35):19024-33. View

17.

Cheng D, Cote J, Shaaban S, Bedford M . The arginine methyltransferase CARM1 regulates the coupling of transcription and mRNA processing. Mol Cell. 2007; 25(1):71-83. DOI: 10.1016/j.molcel.2006.11.019. View

18.

Gary J, Lin W, Yang M, Herschman H, Clarke S . The predominant protein-arginine methyltransferase from Saccharomyces cerevisiae. J Biol Chem. 1996; 271(21):12585-94. DOI: 10.1074/jbc.271.21.12585. View

19.

Chang B, Chen Y, Zhao Y, Bruick R . JMJD6 is a histone arginine demethylase. Science. 2007; 318(5849):444-7. DOI: 10.1126/science.1145801. View

20.

Aletta J, Hu J . Protein arginine methylation in health and disease. Biotechnol Annu Rev. 2008; 14:203-24. DOI: 10.1016/S1387-2656(08)00008-2. View