Cyclic Thymineless Death Significantly Increases Frequency of R-plasmid Elimination

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 1977 Oct 1

PMID 335962

Citations 1

Authors

M J Tribe

R J Pinney

Affiliations

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Abstract

Thymine starvation of Escherichia coli strain C600 thy (R46) eliminated the R plasmid at a frequency of 17%. This was increased fourfold, to 68%, after the same culture was subjected to an additional three cycles of growth followed by thymineless death.

Citing Articles

Use of thymine limitation and thymine starvation to study bacterial physiology and cytology.

Zaritsky A, Woldringh C, Einav M, Alexeeva S J Bacteriol. 2006; 188(5):1667-79.

PMID: 16484178 PMC: 1426543. DOI: 10.1128/JB.188.5.1667-1679.2006.

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