Retrograde Enhancement of Episodic Learning by a Postlearning Stimulus

Overview

Journal Learn Mem

Specialty Neurology

Date 2021 Feb 17

PMID 33593926

Citations 3

Authors

Julian Quintanilla

Brittney M Cox

Christine M Gall

Stephen V Mahler

Gary Lynch

Affiliations

Soon will be listed here.

Abstract

Evidence suggests encoding of recent episodic experiences may be enhanced by a subsequent salient event. We tested this hypothesis by giving rats a 3-min unsupervised experience with four odors and measuring retention after different delays. Animals recognized that a novel element had been introduced to the odor set at 24 but not 48 h. However, when odor sampling was followed within 5 min by salient light flashes or bedding odor, the memory lasted a full 2 d. These results describe a retroactive influence of salience to promote storage of episodic information and introduce a unique model for studying underlying plasticity mechanisms.

Citing Articles

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Gall C, Le A, Lynch G Philos Trans R Soc Lond B Biol Sci. 2024; 379(1906):20230223.

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Sex differences in the context dependency of episodic memory.

Le A, Palmer L, Chavez J, Gall C, Lynch G Front Behav Neurosci. 2024; 18:1349053.

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Persistent sexually dimorphic effects of adolescent THC exposure on hippocampal synaptic plasticity and episodic memory in rodents.

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