Does the Relationship Between 25-hydroxyvitamin D Status and Bone Mass Vary According to Skin Color in Adults? Results of a Brazilian Population-based Study

Overview

Journal Arch Osteoporos

Publisher Springer

Date 2021 Feb 16

PMID 33591401

Citations 1

Authors

Katia Josiany Segheto

Leidjaira Lopes Juvanhol

Danielle Cristina Guimaraes da Silva

Cristiane Junqueira de Carvalho

Fernanda Hansen

Mariana Papini Gabiatti

Adriana Maria Kakehasi

Giana Zarbato Longo

Affiliations

Soon will be listed here.

Abstract

Purpose/introduction: To analyze the association of 25(OH)D with bone mineral content (BMC) and bone mineral density (BMD); and to investigate the presence of interaction with skin color in Brazilian adults.

Methods: This is a cross-sectional, population-based study conducted with adult individuals (20-59 years) of both genders. Bone health was assessed by dual energy radiological absortometry. Vitamin D status was measured using serum 25(OH)D. Skin color and other variables in the adjusted model were collected using a questionnaire and anthropometric assessment. Associations and interactions were evaluated using linear regression models stratified according to gender.

Results: Non-white men with vitamin D deficiency (< 20.0 ng/mL) have less bone mass than those with insufficiency and sufficiency for the femoral neck and hip sites. According to the adjusted regression analysis, the deficient status of 25(OH)D in men was associated with worse bone health for the lumbar spine sites (β = - 0.1; p = 0.006), femoral neck (β = - 0.08; p = 0.006), and hip (β = - 0.08; p = 0.009). No statistically significant associations were observed between 25(OH)D and bone health in women. In addition, no statistical interaction was identified between skin color and vitamin D status in relation to bone health (p > 0.05 for all tests) in either gender and for all bone sites evaluated.

Conclusion: Deficient vitamin D status is associated with lower bone mass in adults with differences observed according to gender, but not according to skin color.

Citing Articles

Prevalence of Vitamin D and Calcium Deficiency and Insufficiency in Women of Childbearing Age and Associated Risk Factors: A Systematic Review and Meta-Analysis.

da Silveira E, Moura L, Castro M, Kac G, Hadler M, Noll P Nutrients. 2022; 14(20).

PMID: 36297034 PMC: 9612098. DOI: 10.3390/nu14204351.

References

Hwang S, Choi H, Kim K, Rhee Y, Lim S . Associations between serum 25-hydroxyvitamin D and bone mineral density and proximal femur geometry in Koreans: the Korean National Health and Nutrition Examination Survey (KNHANES) 2008-2009. Osteoporos Int. 2014; 26(1):163-71. DOI: 10.1007/s00198-014-2877-0. View

Steingrimsdottir L, Halldorsson T, Siggeirsdottir K, Cotch M, Einarsdottir B, Eiriksdottir G . Hip fractures and bone mineral density in the elderly--importance of serum 25-hydroxyvitamin D. PLoS One. 2014; 9(3):e91122. PMC: 3951316. DOI: 10.1371/journal.pone.0091122. View

Moayyeri A, Hammond C, Hart D, Spector T . Effects of age on genetic influence on bone loss over 17 years in women: the Healthy Ageing Twin Study (HATS). J Bone Miner Res. 2012; 27(10):2170-8. DOI: 10.1002/jbmr.1659. View

Gutierrez O, Farwell W, Kermah D, Taylor E . Racial differences in the relationship between vitamin D, bone mineral density, and parathyroid hormone in the National Health and Nutrition Examination Survey. Osteoporos Int. 2010; 22(6):1745-53. PMC: 3093445. DOI: 10.1007/s00198-010-1383-2. View

Demeke T, El-Gawad G, Osmancevic A, Gillstedt M, Landin-Wilhelmsen K . Lower bone mineral density in Somali women living in Sweden compared with African-Americans. Arch Osteoporos. 2015; 10:208. PMC: 4333313. DOI: 10.1007/s11657-015-0208-5. View

Holick M, Binkley N, Bischoff-Ferrari H, Gordon C, Hanley D, Heaney R . Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011; 96(7):1911-30. DOI: 10.1210/jc.2011-0385. View

Fujiyoshi A, Polgreen L, Hurley D, Gross M, Sidney S, Jacobs Jr D . A cross-sectional association between bone mineral density and parathyroid hormone and other biomarkers in community-dwelling young adults: the CARDIA study. J Clin Endocrinol Metab. 2013; 98(10):4038-46. PMC: 3790619. DOI: 10.1210/jc.2013-2198. View

Thoreson C, Chung S, Ricks M, Reynolds J, Remaley A, Periwal V . Biochemical and clinical deficiency is uncommon in African immigrants despite a high prevalence of low vitamin D: the Africans in America study. Osteoporos Int. 2015; 26(11):2607-2615. PMC: 4607556. DOI: 10.1007/s00198-015-3169-z. View

Powe C, Ricciardi C, Berg A, Erdenesanaa D, Collerone G, Ankers E . Vitamin D-binding protein modifies the vitamin D-bone mineral density relationship. J Bone Miner Res. 2011; 26(7):1609-16. PMC: 3351032. DOI: 10.1002/jbmr.387. View

10.

Joo N, Dawson-Hughes B, Yeum K . 25-Hydroxyvitamin D, calcium intake, and bone mineral content in adolescents and young adults: analysis of the fourth and fifth Korea National Health and Nutrition Examination Survey (KNHANES IV-2, 3, 2008-2009 and V-1, 2010). J Clin Endocrinol Metab. 2013; 98(9):3627-36. DOI: 10.1210/jc.2013-1480. View

11.

Lim J, Kim K, Rhee Y, Lim S . Gender-dependent skeletal effects of vitamin D deficiency in a younger generation. J Clin Endocrinol Metab. 2012; 97(6):1995-2004. DOI: 10.1210/jc.2011-3098. View

12.

Segheto W, Silva D, Coelho F, Reis V, Morais S, Marins J . BODY ADIPOSITY INDEX AND ASSOCIATED FACTORS IN ADULTS: METHOD AND LOGISTICS OF A POPULATION-BASED STUDY. Nutr Hosp. 2015; 32(1):101-9. DOI: 10.3305/nh.2015.32.1.8391. View

13.

Lewiecki E, Binkley N, Morgan S, Shuhart C, Camargos B, Carey J . Best Practices for Dual-Energy X-ray Absorptiometry Measurement and Reporting: International Society for Clinical Densitometry Guidance. J Clin Densitom. 2016; 19(2):127-40. DOI: 10.1016/j.jocd.2016.03.003. View

14.

Haskell W, Lee I, Pate R, Powell K, Blair S, Franklin B . Physical activity and public health: updated recommendation for adults from the American College of Sports Medicine and the American Heart Association. Med Sci Sports Exerc. 2007; 39(8):1423-34. DOI: 10.1249/mss.0b013e3180616b27. View

15.

Heaney R, Holick M . Why the IOM recommendations for vitamin D are deficient. J Bone Miner Res. 2011; 26(3):455-7. DOI: 10.1002/jbmr.328. View

16.

Holick M, Binkley N, Bischoff-Ferrari H, Gordon C, Hanley D, Heaney R . Guidelines for preventing and treating vitamin D deficiency and insufficiency revisited. J Clin Endocrinol Metab. 2012; 97(4):1153-8. DOI: 10.1210/jc.2011-2601. View

17.

Ross A, Manson J, Abrams S, Aloia J, Brannon P, Clinton S . The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab. 2010; 96(1):53-8. PMC: 3046611. DOI: 10.1210/jc.2010-2704. View

18.

K Shivane V, Sarathi V, Lila A, Bandgar T, Joshi S, Menon P . Peak bone mineral density and its determinants in an Asian Indian population. J Clin Densitom. 2012; 15(2):152-8. DOI: 10.1016/j.jocd.2011.12.007. View

19.

Hannan M, Litman H, Araujo A, McLennan C, McLean R, McKinlay J . Serum 25-hydroxyvitamin D and bone mineral density in a racially and ethnically diverse group of men. J Clin Endocrinol Metab. 2007; 93(1):40-6. PMC: 2190744. DOI: 10.1210/jc.2007-1217. View

20.

Barbour K, Zmuda J, Horwitz M, Strotmeyer E, Boudreau R, Evans R . The association of serum 25-hydroxyvitamin D with indicators of bone quality in men of Caucasian and African ancestry. Osteoporos Int. 2010; 22(9):2475-85. PMC: 3539808. DOI: 10.1007/s00198-010-1481-1. View