The Association of Serum 25-hydroxyvitamin D with Indicators of Bone Quality in Men of Caucasian and African Ancestry

Overview

Journal Osteoporos Int

Specialties Endocrinology
Orthopedics

Date 2010 Nov 25

PMID 21104232

Citations 12

Authors

K E Barbour

J M Zmuda

M J Horwitz

E S Strotmeyer

R Boudreau

R W Evans

K E Ensrud

C L Gordon

M A Petit

A L Patrick

J A Cauley

Affiliations

Soon will be listed here.

Abstract

Unlabelled: We examined the association of serum 25-hydroxyvitamin D [25(OH)D] with indices of bone quality in older men. Positive associations for 25(OH)D and bone mineral density, content, cortical thickness, and axial and polar strength strain indices were observed among Caucasians; however, among men of African descent findings were either null or negative.

Introduction: There are limited data on serum 25(OH)D and bone measures in men of African ancestry. To better understand racial differences in vitamin D status and bone health, a cross-sectional study among 446 Caucasian men in the US and 496 men of African ancestry in Tobago (age ≥ 65 years) was conducted.

Methods: Serum 25(OH)D (liquid chromatography and tandem mass spectrometry) was measured, and peripheral quantitative computed tomography scans were administered. Bone measures estimated included trabecular and cortical volumetric bone mineral density (vBMD), bone mineral content (BMC), bone geometry (cross-sectional area and cortical thickness), and polar and axial strength strain indices (SSIp and SSIx).

Results: Men of African ancestry had higher 25(OH)D than Caucasians (34.7 vs. 27.6 ng/ml, p < 0.01). Among Caucasians, 25(OH)D was positively (p trend < 0.05) associated with cortical vBMD, total BMC, cortical thickness, SSIp, and SSIx at the distal radius after adjustment for potential confounders. Similar patterns were observed at the distal tibia. In contrast, in men of African ancestry, there was an inverse association (p trend < 0.05) between 25(OH)D and the cross-sectional area, and SSIx. Race modified (p for interaction < 0.05) the association between 25(OH)D and total BMC, cross-sectional area, SSIp, SSIx, and trabecular vBMD of the radius. In men of African ancestry, there was evidence of a threshold effect (at approximately 18 ng/ml) for 25(OH)D on tibial total BMC and cortical thickness.

Conclusions: More studies are needed to better comprehend these race differences for 25(OH)D and bone density, geometry, and indices of bone strength.

Citing Articles

Global Perspective of the Vitamin D Status of African-Caribbean Populations: A Systematic Review and Meta-analysis.

Vearing R, Hart K, Darling A, Probst Y, Olayinka A, Mendis J Eur J Clin Nutr. 2021; 76(4):516-526.

PMID: 34282293 PMC: 8993683. DOI: 10.1038/s41430-021-00980-9.

Does the relationship between 25-hydroxyvitamin D status and bone mass vary according to skin color in adults? Results of a Brazilian population-based study.

Segheto K, Juvanhol L, Silva D, de Carvalho C, Hansen F, Gabiatti M Arch Osteoporos. 2021; 16(1):31.

PMID: 33591401 DOI: 10.1007/s11657-021-00876-y.

Ethnic Variations in Serum 25(OH)D Levels and Bone Ultrasound Attenuation Measurements in Blacks and Whites.

Sakamoto R, Thorpe D, Knutsen R, Beeson L, Knutsen S J Racial Ethn Health Disparities. 2017; 5(2):439-448.

PMID: 28639252 PMC: 6069996. DOI: 10.1007/s40615-017-0387-4.

Three doses of vitamin D, bone mineral density, and geometry in older women during modest weight control in a 1-year randomized controlled trial.

Pop L, Sukumar D, Schneider S, Schlussel Y, Stahl T, Gordon C Osteoporos Int. 2016; 28(1):377-388.

PMID: 27535752 DOI: 10.1007/s00198-016-3735-z.

Vitamin D metabolites and bone mineral density: The multi-ethnic study of atherosclerosis.

van Ballegooijen A, Robinson-Cohen C, Katz R, Criqui M, Budoff M, Li D Bone. 2015; 78:186-93.

PMID: 25976951 PMC: 4466133. DOI: 10.1016/j.bone.2015.05.008.

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