Neuroeffector Actions of Thromboxane B2 in Dog Isolated Mesenteric Arteries

Overview

Journal Br J Pharmacol

Publisher Wiley

Specialty Pharmacology

Date 1988 Feb 1

PMID 3359109

Citations 2

Authors

T Okamura

M Nakajima

N Toda

Affiliations

Soon will be listed here.

Abstract

1. Thromboxane (TX) B2 and epithiomethano (sTXA2), in concentrations that were insufficient to alter the basal tone, potentiated contractile responses of helical strips of dog mesenteric arteries to transmural electrical stimulation. The potentiating effect of TXB2 (up to 10(-6) M) was not abolished by diphloretin phosphate (DPP), a prostaglandin antagonist, whereas the potentiation by sTXA2 was abolished by the antagonist. 2. sTXA2 and TXB2 (3 x 10(-6) M or higher) potentiated the responses to noradrenaline, the potentiation being antagonized by DPP. 3. 3H-overflow evoked by transmural stimulation in superfused arterial strips previously soaked in medium containing [3H]-noradrenaline was increased by TXB2, but not altered by sTXA2. 4. TXB2 in low concentrations potentiated the contractile response to adrenergic nerve stimulation, possibly by increasing the release of noradrenaline, while the potentiation by the TXA2 analogue appears to be due to increased sensitivity of the arteries to noradrenaline. Prejunctional effects of TXB2 may be mediated by receptor sites functionally different from those located postjunctionally.

Citing Articles

Cultured chick sympathetic neurons: prostanoid EP1 receptor-mediated facilitation of noradrenaline release.

Allgaier C, Meder W Naunyn Schmiedebergs Arch Pharmacol. 1995; 352(4):447-50.

PMID: 8532075 DOI: 10.1007/BF00172784.

Modulation of electrically evoked [3H]-noradrenaline release from cultured chick sympathetic neurons.

Allgaier C, Schobert A, Belledin M, Jackisch R, Hertting G Naunyn Schmiedebergs Arch Pharmacol. 1994; 350(3):258-66.

PMID: 7824042 DOI: 10.1007/BF00175031.

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