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Suramin: a Reversible P2-purinoceptor Antagonist in the Mouse Vas Deferens

Overview
Journal Br J Pharmacol
Publisher Wiley
Specialty Pharmacology
Date 1988 Feb 1
PMID 3359103
Citations 159
Authors
P M Dunn
A G BLAKELEY
Affiliations
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Abstract

The trypanocide Suramin was tested as a possible antagonist at the P2-purinoceptor of the mouse vas deferens. At a concentration of 100 microM, Suramin antagonized the response to alpha,beta-methylene ATP, while responses to carbachol and noradrenaline were unaffected. These results suggest that Suramin may provide a starting point for the development of specific antagonists for P2-purinoceptors.

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