Perspectives of Pluripotent Stem Cells in Livestock

Overview

Journal World J Stem Cells

Publisher Baishideng Publishing Group

Date 2021 Feb 15

PMID 33584977

Citations 11

Authors

Dharmendra Kumar

Thirumala R Talluri

Naresh L Selokar

Iqbal Hyder

Wilfried A Kues

Affiliations

Soon will be listed here.

Abstract

The recent progress in derivation of pluripotent stem cells (PSCs) from farm animals opens new approaches not only for reproduction, genetic engineering, treatment and conservation of these species, but also for screening novel drugs for their efficacy and toxicity, and modelling of human diseases. Initial attempts to derive PSCs from the inner cell mass of blastocyst stages in farm animals were largely unsuccessful as either the cells survived for only a few passages, or lost their cellular potency; indicating that the protocols which allowed the derivation of murine or human embryonic stem (ES) cells were not sufficient to support the maintenance of ES cells from farm animals. This scenario changed by the innovation of induced pluripotency and by the development of the 3 inhibitor culture conditions to support naïve pluripotency in ES cells from livestock species. However, the long-term culture of livestock PSCs while maintaining the full pluripotency is still challenging, and requires further refinements. Here, we review the current achievements in the derivation of PSCs from farm animals, and discuss the potential application areas.

Citing Articles

Reporter Alleles in hiPSCs: Visual Cues on Development and Disease.

Cotta G, Teixeira Dos Santos R, Costa G, Lacerda S Int J Mol Sci. 2024; 25(20).

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Mechanisms of Embryonic Stem Cell Pluripotency Maintenance and Their Application in Livestock and Poultry Breeding.

Wang Z, Gong W, Yao Z, Jin K, Niu Y, Li B Animals (Basel). 2024; 14(12).

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Exploring the promising potential of induced pluripotent stem cells in cancer research and therapy.

Chehelgerdi M, Dehkordi F, Chehelgerdi M, Kabiri H, Salehian-Dehkordi H, Abdolvand M Mol Cancer. 2023; 22(1):189.

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How genome editing changed the world of large animal research.

Fischer K, Schnieke A Front Genome Ed. 2023; 5:1272687.

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Perspectives in Genome-Editing Techniques for Livestock.

Popova J, Bets V, Kozhevnikova E Animals (Basel). 2023; 13(16).

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