Towards Human Organ Generation Using Interspecies Blastocyst Complementation: Challenges and Perspectives for Therapy

Overview

Journal Front Cell Dev Biol

Specialty Cell Biology

Date 2023 Feb 6

PMID 36743411

Authors

Hemanta Sarmah

Anri Sawada

Youngmin Hwang

Akihiro Miura

Yuko Shimamura

Junichi Tanaka

Kazuhiko Yamada

Munemasa Mori

Affiliations

Soon will be listed here.

Abstract

Millions of people suffer from end-stage refractory diseases. The ideal treatment option for terminally ill patients is organ transplantation. However, donor organs are in absolute shortage, and sadly, most patients die while waiting for a donor organ. To date, no technology has achieved long-term sustainable patient-derived organ generation. In this regard, emerging technologies of chimeric human organ production blastocyst complementation (BC) holds great promise. To take human organ generation BC and transplantation to the next step, we reviewed current emerging organ generation technologies and the associated efficiency of chimera formation in human cells from the standpoint of developmental biology.

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