Renal Metabolism and Hypertension

Overview

Journal Nat Commun

Specialty Biology

Date 2021 Feb 12

PMID 33574248

Citations 61

Authors

Zhongmin Tian

Mingyu Liang

Affiliations

Soon will be listed here.

Abstract

Hypertension is a leading risk factor for disease burden worldwide. The kidneys, which have a high specific metabolic rate, play an essential role in the long-term regulation of arterial blood pressure. In this review, we discuss the emerging role of renal metabolism in the development of hypertension. Renal energy and substrate metabolism is characterized by several important and, in some cases, unique features. Recent advances suggest that alterations of renal metabolism may result from genetic abnormalities or serve initially as a physiological response to environmental stressors to support tubular transport, which may ultimately affect regulatory pathways and lead to unfavorable cellular and pathophysiological consequences that contribute to the development of hypertension.

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