The Role of MiRNAs, MiRNA Clusters, and IsomiRs in Development of Cancer Stem Cell Populations in Colorectal Cancer

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2021 Feb 12

PMID 33572600

Citations 12

Authors

Victoria A Stark

Caroline O B Facey

Vignesh Viswanathan

Bruce M Boman

Affiliations

Soon will be listed here.

Abstract

MicroRNAs (miRNAs or miRs) have a critical role in regulating stem cells (SCs) during development and altered expression can cause developmental defects and/or disease. Indeed, aberrant miRNA expression leads to wide-spread transcriptional dysregulation which has been linked to many cancers. Mounting evidence also indicates a role for miRNAs in the development of the cancer SC (CSC) phenotype. Our goal herein is to provide a review of: (i) current research on miRNAs and their targets in colorectal cancer (CRC), and (ii) miRNAs that are differentially expressed in colon CSCs. MicroRNAs can work in clusters or alone when targeting different SC genes to influence CSC phenotype. Accordingly, we discuss the specific miRNA cluster classifications and isomiRs that are predicted to target the , , , , and SC genes. and are of particular interest because our previously reported studies on miRNA expression in isolated normal versus malignant human colonic SCs showed that and are regulators of the and SC genes, respectively. We also identify additional miRNAs whose expression inversely correlated with mRNA levels of their target genes and associated with CRC patient survival. Altogether, our deliberation on miRNAs, their clusters, and isomiRs in regulation of SC genes could provide insight into how dysregulation of miRNAs leads to the emergence of different CSC populations and SC overpopulation in CRC.

Citing Articles

L. Extract Inhibits Colorectal Cancer Tumor Growth by Modulating Cell Apoptosis and Autophagy.

Tsai M, Chen C, Chen C, Lee M, Wu L, Hsu Y Curr Issues Mol Biol. 2025; 47(2).

PMID: 39996849 PMC: 11854706. DOI: 10.3390/cimb47020128.

The Role of Tumor Stem Cells in Colorectal Cancer Drug Resistance.

Zhong C, Wang G, Guo M, Zhu N, Chen X, Yan Y Cancer Control. 2024; 31:10732748241274196.

PMID: 39215442 PMC: 11367616. DOI: 10.1177/10732748241274196.

Circular RNA hsa_circ_0005939 Regulates UHRF1BP1L Expression by Targeting miR-4693-3p to Promote Colorectal Cancer Progression.

Ge H, Yan Y, Wang H, Bian J, Deng Z, Su X Protein Pept Lett. 2024; 31(6):437-446.

PMID: 38918974 DOI: 10.2174/0109298665297110240611115010.

Differential miRNA Expression Contributes to Emergence of Multiple Cancer Stem Cell Subpopulations in Human Colorectal Cancer.

Stark V, Facey C, Opdenaker L, Fields J, Boman B J Stem Cell Res Ther. 2024; 13(2).

PMID: 38545373 PMC: 10972542.

Role of non-coding RNAs as new therapeutic targets in regulating the EMT and apoptosis in metastatic gastric and colorectal cancers.

Ebrahimi N, Hakimzadeh A, Bozorgmand F, Speed S, Manavi M, Khorram R Cell Cycle. 2023; 22(20):2302-2323.

PMID: 38009668 PMC: 10730205. DOI: 10.1080/15384101.2023.2286804.

References

Shigeyasu K, Okugawa Y, Toden S, Boland C, Goel A . Exportin-5 Functions as an Oncogene and a Potential Therapeutic Target in Colorectal Cancer. Clin Cancer Res. 2016; 23(5):1312-1322. PMC: 5435115. DOI: 10.1158/1078-0432.CCR-16-1023. View

Roush S, Slack F . The let-7 family of microRNAs. Trends Cell Biol. 2008; 18(10):505-16. DOI: 10.1016/j.tcb.2008.07.007. View

Ma L, Teruya-Feldstein J, Weinberg R . Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature. 2007; 449(7163):682-8. DOI: 10.1038/nature06174. View

Chu P, Clanton D, Snipas T, Lee J, Mitchell E, Nguyen M . Characterization of a subpopulation of colon cancer cells with stem cell-like properties. Int J Cancer. 2008; 124(6):1312-21. DOI: 10.1002/ijc.24061. View

Negrini M, Ferracin M, Sabbioni S, Croce C . MicroRNAs in human cancer: from research to therapy. J Cell Sci. 2007; 120(Pt 11):1833-40. DOI: 10.1242/jcs.03450. View

Shi Y, Liu Z . Serum miR-92a-1 is a novel diagnostic biomarker for colorectal cancer. J Cell Mol Med. 2020; 24(15):8363-8367. PMC: 7412696. DOI: 10.1111/jcmm.15282. View

Naidu S, Shi L, Magee P, Middleton J, Lagana A, Sahoo S . PDGFR-modulated miR-23b cluster and miR-125a-5p suppress lung tumorigenesis by targeting multiple components of KRAS and NF-kB pathways. Sci Rep. 2017; 7(1):15441. PMC: 5684387. DOI: 10.1038/s41598-017-14843-6. View

Meder L, Konig K, Dietlein F, Macheleidt I, Florin A, Ercanoglu M . LIN28B enhanced tumorigenesis in an autochthonous KRAS-driven lung carcinoma mouse model. Oncogene. 2018; 37(20):2746-2756. DOI: 10.1038/s41388-018-0158-7. View

Rukov J, Wilentzik R, Jaffe I, Vinther J, Shomron N . Pharmaco-miR: linking microRNAs and drug effects. Brief Bioinform. 2013; 15(4):648-59. PMC: 4103536. DOI: 10.1093/bib/bbs082. View

10.

Lopez-Bertoni H, Lal B, Michelson N, Guerrero-Cazares H, Quinones-Hinojosa A, Li Y . Epigenetic modulation of a miR-296-5p:HMGA1 axis regulates Sox2 expression and glioblastoma stem cells. Oncogene. 2016; 35(37):4903-13. PMC: 6151872. DOI: 10.1038/onc.2016.22. View

11.

Kozomara A, Birgaoanu M, Griffiths-Jones S . miRBase: from microRNA sequences to function. Nucleic Acids Res. 2018; 47(D1):D155-D162. PMC: 6323917. DOI: 10.1093/nar/gky1141. View

12.

Khan A, Ahmed E, Elareer N, Junejo K, Steinhoff M, Uddin S . Role of miRNA-Regulated Cancer Stem Cells in the Pathogenesis of Human Malignancies. Cells. 2019; 8(8). PMC: 6721829. DOI: 10.3390/cells8080840. View

13.

Iorio M, Ferracin M, Liu C, Veronese A, Spizzo R, Sabbioni S . MicroRNA gene expression deregulation in human breast cancer. Cancer Res. 2005; 65(16):7065-70. DOI: 10.1158/0008-5472.CAN-05-1783. View

14.

Vaksman O, Hetland T, Trope C, Reich R, Davidson B . Argonaute, Dicer, and Drosha are up-regulated along tumor progression in serous ovarian carcinoma. Hum Pathol. 2012; 43(11):2062-9. DOI: 10.1016/j.humpath.2012.02.016. View

15.

Ma H, Pan J, Jin L, Wu J, Ren Y, Chen P . MicroRNA-17~92 inhibits colorectal cancer progression by targeting angiogenesis. Cancer Lett. 2016; 376(2):293-302. DOI: 10.1016/j.canlet.2016.04.011. View

16.

Viswanathan V, Fields J, Boman B . The miRNA23b-regulated signaling network as a key to cancer development--implications for translational research and therapeutics. J Mol Med (Berl). 2014; 92(11):1129-38. DOI: 10.1007/s00109-014-1208-4. View

17.

Ottman R, Levy J, Grizzle W, Chakrabarti R . The other face of miR-17-92a cluster, exhibiting tumor suppressor effects in prostate cancer. Oncotarget. 2016; 7(45):73739-73753. PMC: 5340125. DOI: 10.18632/oncotarget.12061. View

18.

Dalerba P, Dylla S, Park I, Liu R, Wang X, Cho R . Phenotypic characterization of human colorectal cancer stem cells. Proc Natl Acad Sci U S A. 2007; 104(24):10158-63. PMC: 1891215. DOI: 10.1073/pnas.0703478104. View

19.

Viswanathan V, Opdenaker L, Modarai S, Fields J, Gonye G, Boman B . MicroRNA Expression Profiling of Normal and Malignant Human Colonic Stem Cells Identifies as a Regulator of the Stem Cell Gene. Int J Mol Sci. 2020; 21(8). PMC: 7216254. DOI: 10.3390/ijms21082804. View

20.

Denli A, Tops B, Plasterk R, Ketting R, Hannon G . Processing of primary microRNAs by the Microprocessor complex. Nature. 2004; 432(7014):231-5. DOI: 10.1038/nature03049. View