Ameliorative Effects of Loganin on Arthritis in Chondrocytes and Destabilization of the Medial Meniscus-Induced Animal Model

Overview

Journal Pharmaceuticals (Basel)

Publisher MDPI

Specialty Chemistry

Date 2021 Feb 11

PMID 33567513

Citations 5

Authors

Eunkuk Park

Chang Gun Lee

Seung Hee Yun

Seokjin Hwang

Hyoju Jeon

Jeonghyun Kim

Subin Yeo

Hyesoo Jeong

Seong-Hoon Yun

Seon-Yong Jeong

Affiliations

Soon will be listed here.

Abstract

Arthritis is a common inflammatory disease that causes pain, stiffness, and joint swelling. Here, we investigated the ameliorative effects of loganin on arthritis in vitro and in vivo. A single bioactive compound was fractionated and isolated from (CO) extract to screen for anti-arthritic effects. A single component, loganin, was identified as a candidate. The CO extract and loganin inhibited the expression of factors associated with cartilage degradation, such as cyclooxygenase-2 (COX-2), matrix metalloproteinase 3 (MMP-3), and matrix metalloproteinase 13 (MMP-13), in interukin-1 beta (IL-1β)-induced chondrocyte inflammation. In addition, prostaglandin and collagenase levels were reduced following treatment of IL-1β-induced chondrocytes with loganin. In the destabilization of the medial meniscus (DMM)-induced mouse model, loganin administration attenuated cartilage degeneration by inhibiting COX-2, MMP-3, and MMP-13. Transverse micro-CT images revealed that loganin reduced DMM-induced osteophyte formation. These results indicate that loganin has protective effects in DMM-induced mice.

Citing Articles

Mechanistic and therapeutic insights into the function of N6-methyladenosine in arthritic diseases.

Zhou X, Wu Y, Song Y, Wang B, Cai Y, Miao C Inflamm Res. 2025; 74(1):7.

PMID: 39762508 DOI: 10.1007/s00011-024-01969-3.

Investigating the protective effect of loganin in ovariectomy‑induced bone loss through network pharmacology and molecular docking.

Xie Y, Qin X, Zhou T, Zhou Y, Tang L, Wang J Exp Ther Med. 2024; 28(5):417.

PMID: 39301261 PMC: 11411401. DOI: 10.3892/etm.2024.12706.

Iridoids and active ones in : A review.

Wang L, Meng X, Zhou H, Liu Y, Zhang Y, Liang H Heliyon. 2023; 9(6):e16518.

PMID: 37292326 PMC: 10245019. DOI: 10.1016/j.heliyon.2023.e16518.

Cornelian Cherry ( L.) Iridoid and Anthocyanin-Rich Extract Reduces Various Oxidation, Inflammation, and Adhesion Markers in a Cholesterol-Rich Diet Rabbit Model.

Danielewski M, Gomulkiewicz A, Kucharska A, Matuszewska A, Nowak B, Piorecki N Int J Mol Sci. 2023; 24(4).

PMID: 36835296 PMC: 9959706. DOI: 10.3390/ijms24043890.

Anti-Osteoarthritic Effects of Prunella Vulgaris and Gentiana Lutea In Vitro and In Vivo.

Kim J, Lee C, Hwang S, Yun S, Uprety L, Oh K Antioxidants (Basel). 2023; 12(1).

PMID: 36670908 PMC: 9854930. DOI: 10.3390/antiox12010047.

References

Casper-Taylor M, Barr A, Williams S, Wilcox R, Conaghan P . Initiating factors for the onset of OA: A systematic review of animal bone and cartilage pathology in OA. J Orthop Res. 2020; 38(8):1810-1818. PMC: 7383628. DOI: 10.1002/jor.24605. View

Aida Y, Maeno M, Suzuki N, Shiratsuchi H, Motohashi M, Matsumura H . The effect of IL-1beta on the expression of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in human chondrocytes. Life Sci. 2005; 77(25):3210-21. DOI: 10.1016/j.lfs.2005.05.052. View

Skioldebrand E, Thorfve A, Bjorklund U, Johansson P, Wickelgren R, Lindahl A . Biochemical alterations in inflammatory reactive chondrocytes: evidence for intercellular network communication. Heliyon. 2018; 4(1):e00525. PMC: 5857518. DOI: 10.1016/j.heliyon.2018.e00525. View

Akhtar N, Khan N, Ashruf O, Haqqi T . Inhibition of cartilage degradation and suppression of PGE and MMPs expression by pomegranate fruit extract in a model of posttraumatic osteoarthritis. Nutrition. 2016; 33:1-13. PMC: 5137805. DOI: 10.1016/j.nut.2016.08.004. View

Mandl L . Osteoarthritis year in review 2018: clinical. Osteoarthritis Cartilage. 2018; 27(3):359-364. DOI: 10.1016/j.joca.2018.11.001. View

Moon S, Lee S, Han S, Park B, Choi M, Kim J . Aqueous extract of Codium fragile alleviates osteoarthritis through the MAPK/NF-κB pathways in IL-1β-induced rat primary chondrocytes and a rat osteoarthritis model. Biomed Pharmacother. 2017; 97:264-270. DOI: 10.1016/j.biopha.2017.10.130. View

Sohn D, Kim H, Kim S, Lee E, Kim H, Kim J . Elevation of intracavernous pressure and NO-cGMP activity by a new herbal formula in penile tissues of spontaneous hypertensive male rats. J Ethnopharmacol. 2008; 120(2):176-80. DOI: 10.1016/j.jep.2008.08.005. View

Philipot D, Guerit D, Platano D, Chuchana P, Olivotto E, Espinoza F . p16INK4a and its regulator miR-24 link senescence and chondrocyte terminal differentiation-associated matrix remodeling in osteoarthritis. Arthritis Res Ther. 2014; 16(1):R58. PMC: 4060445. DOI: 10.1186/ar4494. View

Cheng Y, Chu L, Chen J, Hsieh S, Chang Y, Dai Z . Loganin Attenuates High Glucose-Induced Schwann Cells Pyroptosis by Inhibiting ROS Generation and NLRP3 Inflammasome Activation. Cells. 2020; 9(9). PMC: 7564733. DOI: 10.3390/cells9091948. View

10.

Chi S, Rattner J, Matyas J . Communication between paired chondrocytes in the superficial zone of articular cartilage. J Anat. 2004; 205(5):363-70. PMC: 1571362. DOI: 10.1111/j.0021-8782.2004.00350.x. View

11.

Khan T, Ali M, Khan A, Nisar P, Jan S, Afridi S . Anticancer Plants: A Review of the Active Phytochemicals, Applications in Animal Models, and Regulatory Aspects. Biomolecules. 2020; 10(1). PMC: 7022400. DOI: 10.3390/biom10010047. View

12.

Czerwinska M, Melzig M . and -Analogies and Differences of Two Medicinal Plants Traditionally Used. Front Pharmacol. 2018; 9:894. PMC: 6121078. DOI: 10.3389/fphar.2018.00894. View

13.

Hunter D, Bierma-Zeinstra S . Osteoarthritis. Lancet. 2019; 393(10182):1745-1759. DOI: 10.1016/S0140-6736(19)30417-9. View

14.

Houard X, Goldring M, Berenbaum F . Homeostatic mechanisms in articular cartilage and role of inflammation in osteoarthritis. Curr Rheumatol Rep. 2013; 15(11):375. PMC: 3989071. DOI: 10.1007/s11926-013-0375-6. View

15.

Carpintero-Fernandez P, Varela-Eirin M, Lacetera A, Gago-Fuentes R, Fonseca E, Martin-Santamaria S . New Therapeutic Strategies for Osteoarthritis by Targeting Sialic Acid Receptors. Biomolecules. 2020; 10(4). PMC: 7226619. DOI: 10.3390/biom10040637. View

16.

Fang H, Huang L, Welch I, Norley C, Holdsworth D, Beier F . Early Changes of Articular Cartilage and Subchondral Bone in The DMM Mouse Model of Osteoarthritis. Sci Rep. 2018; 8(1):2855. PMC: 5809364. DOI: 10.1038/s41598-018-21184-5. View

17.

Cho H, Walker A, Williams J, Hasty K . Study of osteoarthritis treatment with anti-inflammatory drugs: cyclooxygenase-2 inhibitor and steroids. Biomed Res Int. 2015; 2015:595273. PMC: 4427003. DOI: 10.1155/2015/595273. View

18.

Oike J, Okumo T, Ikemoto H, Kunieda Y, Nakai S, Takemura H . Preventive Effect of the Japanese Traditional Herbal Medicine Boiogito on Posttraumatic Osteoarthritis in Rats. Medicines (Basel). 2020; 7(12). PMC: 7761896. DOI: 10.3390/medicines7120074. View

19.

Hu J, Zhou J, Wu J, Chen Q, Du W, Fu F . Loganin ameliorates cartilage degeneration and osteoarthritis development in an osteoarthritis mouse model through inhibition of NF-κB activity and pyroptosis in chondrocytes. J Ethnopharmacol. 2019; 247:112261. DOI: 10.1016/j.jep.2019.112261. View

20.

Henrotin Y, Mobasheri A . Natural Products for Promoting Joint Health and Managing Osteoarthritis. Curr Rheumatol Rep. 2018; 20(11):72. DOI: 10.1007/s11926-018-0782-9. View