Iridoids and Active Ones in : A Review

Overview

Journal Heliyon

Specialty Social Sciences

Date 2023 Jun 9

PMID 37292326

Authors

Li Wang

Xinjing Meng

Huihui Zhou

Yuhang Liu

Yadan Zhang

Haiyang Liang

Gaixia Hou

Wenyi Kang

Zhenhua Liu

Affiliations

Soon will be listed here.

Abstract

Iridoid is a special class of monoterpenoids, whose basic skeleton is the acetal derivative of antinodilaldehyde with a bicyclic H-5/H-9, -cisfused cyclopentan pyran ring. They were often existed in Valerianaceae, Rubiaceae, Scrophulariaceae and Labiaceae family, and has various biological activities, such as anti-inflammatory, hypoglycemic, neuroprotection, and soon. In this review, iridoids from (Valerianaceae family), and the active ones as well as their mechanisms in recent 20 years were summarized. Up to now, a total of 115 iridoids had been identified in , among which 48 had extensive biological activities mainly presented in anti-inflammatory, anti-tumor and neuroprotective. And the mechanisms involved in MAPK, NF-κB and JNK signal pathways. The summary for iridoids and their activities will provide the evidence to exploit the iridoids in .

Citing Articles

Genipin-Simple but Significant Bioactive Iridoid for Therapeutical Application and Beyond: A Review.

Sobolewska D, Galanty A, Grabowska K, Makowska-Was J, Podolak I, Wrobel-Biedrawa D Life (Basel). 2025; 15(2).

PMID: 40003568 PMC: 11856651. DOI: 10.3390/life15020159.

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