Carotenoids and Some Other Pigments from Fungi and Yeasts

Overview

Journal Metabolites

Publisher MDPI

Date 2021 Feb 10

PMID 33561985

Citations 24

Authors

Alexander Rapoport

Irina Guzhova

Lorenzo Bernetti

Pietro Buzzini

Marek Kieliszek

Anna Maria Kot

Affiliations

Soon will be listed here.

Abstract

Carotenoids are an essential group of compounds that may be obtained by microbiological synthesis. They are instrumental in various areas of industry, medicine, agriculture, and ecology. The increase of carotenoids' demand at the global market is now essential. At the moment, the production of natural carotenoids is more expensive than obtaining their synthetic forms, but several new approaches/directions on how to decrease this difference were developed during the last decades. This review briefly describes the information accumulated until now about the beneficial effects of carotenoids on human health protection, their possible application in the treatments of various diseases, and their use in the food and feed industry. This review also describes some issues that are linked with biotechnological production of fungal and yeasts carotenoids, as well as new approaches/directions to make their biotechnological production more efficient.

Citing Articles

Pigment Production by sp.: Extract Production, Cytotoxicity Activity, and Diketopiperazines Identified.

Alves B, Borges L, Hanna S, Soares M, Bezerra D, Moreira L Microorganisms. 2025; 13(2).

PMID: 40005644 PMC: 11857561. DOI: 10.3390/microorganisms13020277.

The legacy of endophytes for the formation of bioactive agents, pigments, biofertilizers, nanoparticles and bioremediation of environment.

Panwar A, Manna S, Sahini G, Kaushik V, Kumar M, Govarthanan M World J Microbiol Biotechnol. 2025; 41(2):52.

PMID: 39871057 DOI: 10.1007/s11274-025-04265-2.

The Application of Fungi and Their Secondary Metabolites in Aquaculture.

Onomu A, Okuthe G J Fungi (Basel). 2024; 10(10).

PMID: 39452663 PMC: 11508898. DOI: 10.3390/jof10100711.

Microbes' role in environmental pollution and remediation: a bioeconomy focus approach.

Maglione G, Zinno P, Tropea A, Mussagy C, Dufosse L, Giuffrida D AIMS Microbiol. 2024; 10(3):723-755.

PMID: 39219757 PMC: 11362270. DOI: 10.3934/microbiol.2024033.

Enhancing bioprocessing of red pigment from immobilized culture of gamma rays mutant of the endophytic fungus Monascus ruber SRZ112.

El-Sayed E, Mousa S, Strzala T, Boratynski F J Biol Eng. 2024; 18(1):44.

PMID: 39148082 PMC: 11325623. DOI: 10.1186/s13036-024-00439-y.

References

Britton G . Carotenoid research: History and new perspectives for chemistry in biological systems. Biochim Biophys Acta Mol Cell Biol Lipids. 2020; 1865(11):158699. DOI: 10.1016/j.bbalip.2020.158699. View

Aziz E, Batool R, Akhtar W, Rehman S, Shahzad T, Malik A . Xanthophyll: Health benefits and therapeutic insights. Life Sci. 2019; 240:117104. DOI: 10.1016/j.lfs.2019.117104. View

Martinez-Moya P, Niehaus K, Alcaino J, Baeza M, Cifuentes V . Proteomic and metabolomic analysis of the carotenogenic yeast Xanthophyllomyces dendrorhous using different carbon sources. BMC Genomics. 2015; 16:289. PMC: 4404605. DOI: 10.1186/s12864-015-1484-6. View

Kiokias S, Gordon M . Dietary supplementation with a natural carotenoid mixture decreases oxidative stress. Eur J Clin Nutr. 2003; 57(9):1135-40. DOI: 10.1038/sj.ejcn.1601655. View

Ramesh C, Vinithkumar N, Kirubagaran R, Venil C, Dufosse L . Multifaceted Applications of Microbial Pigments: Current Knowledge, Challenges and Future Directions for Public Health Implications. Microorganisms. 2019; 7(7). PMC: 6680428. DOI: 10.3390/microorganisms7070186. View

Mussagy C, Winterburn J, Santos-Ebinuma V, Pereira J . Production and extraction of carotenoids produced by microorganisms. Appl Microbiol Biotechnol. 2018; 103(3):1095-1114. DOI: 10.1007/s00253-018-9557-5. View

Rao L, Mackinnon E, Josse R, Murray T, Strauss A, Rao A . Lycopene consumption decreases oxidative stress and bone resorption markers in postmenopausal women. Osteoporos Int. 2006; 18(1):109-15. DOI: 10.1007/s00198-006-0205-z. View

Sandmann G . Genetic manipulation of carotenoid biosynthesis: strategies, problems and achievements. Trends Plant Sci. 2001; 6(1):14-7. DOI: 10.1016/s1360-1385(00)01817-3. View

Melendez-Martinez A, Stinco C, Mapelli-Brahm P . Skin Carotenoids in Public Health and Nutricosmetics: The Emerging Roles and Applications of the UV Radiation-Absorbing Colourless Carotenoids Phytoene and Phytofluene. Nutrients. 2019; 11(5). PMC: 6566388. DOI: 10.3390/nu11051093. View

10.

Bendich A . Carotenoids and the immune response. J Nutr. 1989; 119(1):112-5. DOI: 10.1093/jn/119.1.112. View

11.

Godara A, Rodriguez M, Weatherston J, Peabody G, Wu H, Kao K . Beneficial mutations for carotenoid production identified from laboratory-evolved Saccharomyces cerevisiae. J Ind Microbiol Biotechnol. 2019; 46(12):1793-1804. DOI: 10.1007/s10295-019-02241-y. View

12.

Kanno K, Karp S, Rodrigues C, Oliveira de Andrade Tanobe V, Soccol C, da Costa Cardoso L . Influence of organic solvents in the extraction and purification of torularhodin from Sporobolomyces ruberrimus. Biotechnol Lett. 2020; 43(1):89-98. DOI: 10.1007/s10529-020-03023-8. View

13.

Fathi Z, Tramontin L, Ebrahimipour G, Borodina I, Darvishi F . Metabolic engineering of Saccharomyces cerevisiae for production of β-carotene from hydrophobic substrates. FEMS Yeast Res. 2020; 21(1). PMC: 7811509. DOI: 10.1093/femsyr/foaa068. View

14.

Riso P, Brusamolino A, Scalfi L, Porrini M . Bioavailability of carotenoids from spinach and tomatoes. Nutr Metab Cardiovasc Dis. 2004; 14(3):150-6. DOI: 10.1016/s0939-4753(04)80035-8. View

15.

Nishino H, Tokuda H, Murakoshi M, Satomi Y, Masuda M, Onozuka M . Cancer prevention by natural carotenoids. Biofactors. 2001; 13(1-4):89-94. DOI: 10.1002/biof.5520130115. View

16.

Nevzgliadova O, Artemov A, Mittenberg A, Mikhailova E, Kuznetsova I, Turoverov K . [The effect of red pigment on amyloidization of yeast proteins]. Tsitologiia. 2010; 52(1):80-93. View

17.

Kim J, Paik J, Kim O, Park H, Lee J, Jang Y . Effects of lycopene supplementation on oxidative stress and markers of endothelial function in healthy men. Atherosclerosis. 2011; 215(1):189-95. DOI: 10.1016/j.atherosclerosis.2010.11.036. View

18.

Eggersdorfer M, Wyss A . Carotenoids in human nutrition and health. Arch Biochem Biophys. 2018; 652:18-26. DOI: 10.1016/j.abb.2018.06.001. View

19.

Miller K, Alper H . Yarrowia lipolytica: more than an oleaginous workhorse. Appl Microbiol Biotechnol. 2019; 103(23-24):9251-9262. DOI: 10.1007/s00253-019-10200-x. View

20.

Das A, Yoon S, Lee S, Kim J, Oh D, Kim S . An update on microbial carotenoid production: application of recent metabolic engineering tools. Appl Microbiol Biotechnol. 2007; 77(3):505-12. DOI: 10.1007/s00253-007-1206-3. View