Stem Cell Secretome, Regeneration, and Clinical Translation: a Narrative Review

Overview

Journal Ann Transl Med

Publisher AME Publishing Company

Date 2021 Feb 8

PMID 33553363

Citations 17

Authors

Chukwuweike Gwam

Nequesha Mohammed

Xue Ma

Affiliations

Soon will be listed here.

Abstract

Regenerative medicine is a field growing in popularity due to high hopes for stimulating tissue restoration. Stem cell therapy remain at the center of regenerative medicine, due to early reports on its pluripotent differentiating capability. However, more recent reports suggest the paracrine activity of stem cells, and not direct differentiation, as the cause of its therapeutic effects. This paracrine activity can be harnessed in the form of conditioned media. Despite these capabilities, the clinical translation of stem cell conditioned media (i.e., secretome) is precluded by a variety of factors. These limitations include standardization of stem cell-conditioned media formulation, characterization of bioactive factors in conditioned media and dosing, optimizing modes of delivery, and uncovering of mechanisms of action of stem cell conditioned media. The purpose of this review is to provide a focused narration on the aforementioned preclusions pertaining to the clinical translation of stem cell conditioned media. Specifically, we will report on commonly use methodologies for the development of stem cell conditioned media, modalities for conditioned media characterization, modes of delivery, and postulated mechanisms of action for stem cell conditioned media in regenerative medicine.

Citing Articles

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Secretome from hypoxic mesenchymal stem cells as a potential therapy for ischemic stroke: Investigations on and expression.

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Isolation, Expansion, and Characterization of Rat Hair Follicle Stem Cells and Their Secretome: Insights into Wound Healing Potential.

Sousa P, Lopes B, Sousa A, Coelho A, de Sousa Moreira A, Rema A Biomedicines. 2025; 12(12.

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A Novel Deer Antler-Inspired Bone Graft Triggers Rapid Bone Regeneration.

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