Monocyte CD169 Expression in COVID-19 Patients Upon Intensive Care Unit Admission

Overview

Journal Cytometry A

Specialties Cell Biology
Radiology

Date 2021 Feb 6

PMID 33547747

Citations 14

Authors

Marine Ortillon

Remy Coudereau

Martin Cour

Thomas Rimmele

Marine Godignon

Morgane Gossez

Hodane Yonis

Laurent Argaud

Anne-Claire Lukaszewicz

Fabienne Venet

Guillaume Monneret

Affiliations

Soon will be listed here.

Abstract

During the second surge of COVID-19 in France (fall 2020), we assessed the expression of monocyte CD169 (i.e., Siglec-1, one of the numerous IFN-stimulated genes) upon admission to intensive care units of 45 patients with RT-PCR-confirmed SARS-CoV2 pulmonary infection. Overall, CD169 expression was strongly induced on circulating monocytes of COVID-19 patients compared with healthy donors and patients with bacterial sepsis. Beyond its contribution at the emergency department, CD169 testing may be also helpful for patients' triage at the ICU to rapidly reinforce suspicion of COVID-19 etiology in patients with acute respiratory failure awaiting for PCR results for definitive diagnosis.

Citing Articles

Role of MR-proADM and Monocyte CD169 in Predicting In-Hospital and 60-Day Mortality in COVID-19 Patients.

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ADTnorm: Robust Integration of Single-cell Protein Measurement across CITE-seq Datasets.

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The Dysregulation of the Monocyte-Dendritic Cell Interplay Is Associated with In-Hospital Mortality in COVID-19 Pneumonia.

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Kinetics of CD169, HLA-DR, and CD64 expression as predictive biomarkers of SARS-CoV2 outcome.

Gatti A, Fassini P, Mazzone A, Rusconi S, Brando B, Mistraletti G J Anesth Analg Crit Care. 2023; 3(1):6.

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SARS-CoV-2 spike protein induces a differential monocyte activation that may contribute to age bias in COVID-19 severity.

Ait-Belkacem I, Cartagena Garcia C, Millet-Wallisky E, Izquierdo N, Loosveld M, Arnoux I Sci Rep. 2022; 12(1):20824.

PMID: 36460710 PMC: 9716544. DOI: 10.1038/s41598-022-25259-2.

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