Disturbance in Mammalian Cognition Caused by Accumulation of Silver in Brain

Overview

Journal Toxics

Date 2021 Feb 6

PMID 33546349

Citations 6

Authors

Anna A Antsiferova

Marina Yu Kopaeva

Vyacheslav N Kochkin

Pavel K Kashkarov

Mikhail V Kovalchuk

Affiliations

Soon will be listed here.

Abstract

The influence of daily prolonged administration of silver nanoparticles on the cognitive functions of a model mammal was studied. The accumulation of silver in the whole brain and the hippocampus, cerebellum, cortex and residual brain tissue of the mouse was investigated by highly precise and representative neutron activation analysis, and histological studies were conducted. Here, we show that long-term memory impairments were caused by the accumulation of silver nanoparticles in the brain and its subregions, such as the hippocampus, cerebellum and cortex, in a step-like manner by disturbance of hippocampal cell integrity. Three different approaches allowed us to observe this phenomenon and discover the reasons it occurred.

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