Editorial: TGF-β As a Key Regulator of NK and ILCs Development and Functions

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2021 Feb 5

PMID 33542726

Citations 2

Authors

Cristina Bottino

Thierry Walzer

Angela Santoni

Roberta Castriconi

Affiliations

Soon will be listed here.

Citing Articles

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Gao X, Wang Q, He H, Yang T, Zhang H, Zhao J Mol Cell Biochem. 2023; 479(7):1721-1733.

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B7-H3 in Pediatric Tumors: Far beyond Neuroblastoma.

Bottino C, Vitale C, Dondero A, Castriconi R Cancers (Basel). 2023; 15(13).

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References

Lan Y, Zhang D, Xu C, Hance K, Marelli B, Qi J . Enhanced preclinical antitumor activity of M7824, a bifunctional fusion protein simultaneously targeting PD-L1 and TGF-β. Sci Transl Med. 2018; 10(424). DOI: 10.1126/scitranslmed.aan5488. View

Ullrich E, Koch J, Cerwenka A, Steinle A . New prospects on the NKG2D/NKG2DL system for oncology. Oncoimmunology. 2013; 2(10):e26097. PMC: 3862635. DOI: 10.4161/onci.26097. View

Regis S, Caliendo F, Dondero A, Casu B, Romano F, Loiacono F . TGF-β1 Downregulates the Expression of CXCR1 by Inducing miR-27a-5p in Primary Human NK Cells. Front Immunol. 2017; 8:868. PMC: 5524732. DOI: 10.3389/fimmu.2017.00868. View

Selvarajah B, Azuelos I, Plate M, Guillotin D, Forty E, Contento G . mTORC1 amplifies the ATF4-dependent de novo serine-glycine pathway to supply glycine during TGF-β-induced collagen biosynthesis. Sci Signal. 2019; 12(582). PMC: 6584619. DOI: 10.1126/scisignal.aav3048. View

Clayton A, Mitchell J, Court J, Linnane S, Mason M, Tabi Z . Human tumor-derived exosomes down-modulate NKG2D expression. J Immunol. 2008; 180(11):7249-58. DOI: 10.4049/jimmunol.180.11.7249. View

Marcais A, Cherfils-Vicini J, Viant C, Degouve S, Viel S, Fenis A . The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells. Nat Immunol. 2014; 15(8):749-757. PMC: 4110708. DOI: 10.1038/ni.2936. View

Casu B, Dondero A, Regis S, Caliendo F, Petretto A, Bartolucci M . Novel Immunoregulatory Functions of IL-18, an Accomplice of TGF-β1. Cancers (Basel). 2019; 11(1). PMC: 6356463. DOI: 10.3390/cancers11010075. View

Zingoni A, Vulpis E, Loconte L, Santoni A . NKG2D Ligand Shedding in Response to Stress: Role of ADAM10. Front Immunol. 2020; 11:447. PMC: 7109295. DOI: 10.3389/fimmu.2020.00447. View

Shull M, Ormsby I, Kier A, Pawlowski S, Diebold R, Yin M . Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease. Nature. 1992; 359(6397):693-9. PMC: 3889166. DOI: 10.1038/359693a0. View

10.

Zaiatz-Bittencourt V, Finlay D, Gardiner C . Canonical TGF-β Signaling Pathway Represses Human NK Cell Metabolism. J Immunol. 2018; 200(12):3934-3941. DOI: 10.4049/jimmunol.1701461. View

11.

Cortez V, Ulland T, Cervantes-Barragan L, Bando J, Robinette M, Wang Q . SMAD4 impedes the conversion of NK cells into ILC1-like cells by curtailing non-canonical TGF-β signaling. Nat Immunol. 2017; 18(9):995-1003. PMC: 5712491. DOI: 10.1038/ni.3809. View

12.

Fionda C, Stabile H, Cerboni C, Soriani A, Gismondi A, Cippitelli M . Hitting More Birds with a Stone: Impact of TGF-β on ILC Activity in Cancer. J Clin Med. 2020; 9(1). PMC: 7019362. DOI: 10.3390/jcm9010143. View

13.

Viel S, Marcais A, Guimaraes F, Loftus R, Rabilloud J, Grau M . TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathway. Sci Signal. 2016; 9(415):ra19. DOI: 10.1126/scisignal.aad1884. View

14.

Kovacs R, Maldonado G, Azaro A, Fernandez M, Romero F, Sepulveda-Sanchez J . Cardiac Safety of TGF-β Receptor I Kinase Inhibitor LY2157299 Monohydrate in Cancer Patients in a First-in-Human Dose Study. Cardiovasc Toxicol. 2014; 15(4):309-23. PMC: 4575352. DOI: 10.1007/s12012-014-9297-4. View

15.

Gao Y, Souza-Fonseca-Guimaraes F, Bald T, Ng S, Young A, Ngiow S . Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cells. Nat Immunol. 2017; 18(9):1004-1015. DOI: 10.1038/ni.3800. View