Transient Receptor Potential Channels in Sensory Mechanisms of the Lower Urinary Tract

Overview

Journal Nat Rev Urol

Specialty Urology

Date 2021 Feb 4

PMID 33536636

Citations 20

Authors

Matthias Vanneste

Andrei Segal

Thomas Voets

Wouter Everaerts

Affiliations

Soon will be listed here.

Abstract

Disruptions to sensory pathways in the lower urinary tract commonly occur and can give rise to lower urinary tract symptoms (LUTS). The unmet clinical need for treatment of LUTS has stimulated research into the molecular mechanisms that underlie neuronal control of the bladder and transient receptor potential (TRP) channels have emerged as key regulators of the sensory processes that regulate bladder function. TRP channels function as molecular sensors in urothelial cells and afferent nerve fibres and can be considered the origin of bladder sensations. TRP channels in the lower urinary tract contribute to the generation of normal and abnormal bladder sensations through a variety of mechanisms, and have demonstrated potential as targets for the treatment of LUTS in functional disorders of the lower urinary tract.

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