Vanilloid Receptor-related Osmotically Activated Channel (VR-OAC), a Candidate Vertebrate Osmoreceptor

Overview

Journal Cell

Publisher Cell Press

Specialty Cell Biology

Date 2000 Nov 18

PMID 11081638

Citations 566

Authors

W Liedtke

Y Choe

A M Bell

C S Denis

A Sali

A J Hudspeth

J M Friedman

S Heller

Affiliations

Soon will be listed here.

Abstract

The detection of osmotic stimuli is essential for all organisms, yet few osmoreceptive proteins are known, none of them in vertebrates. By employing a candidate-gene approach based on genes encoding members of the TRP superfamily of ion channels, we cloned cDNAs encoding the vanilloid receptor-related osmotically activated channel (VR-OAC) from the rat, mouse, human, and chicken. This novel cation-selective channel is gated by exposure to hypotonicity within the physiological range. In the central nervous system, the channel is expressed in neurons of the circumventricular organs, neurosensory cells responsive to systemic osmotic pressure. The channel also occurs in other neurosensory cells, including inner-ear hair cells, sensory neurons, and Merkel cells.

Citing Articles

Research progress of TRPV4 in pain over the past 20 years: a bibliometric analysis.

Huang L, Xuan Q, Li Y, Huang J, Fang F Naunyn Schmiedebergs Arch Pharmacol. 2025; .

PMID: 39951114 DOI: 10.1007/s00210-025-03846-0.

Thermo-TRP regulation by endogenous factors and its physiological function at core body temperature.

Kashio M Physiol Rep. 2025; 13(1):e70164.

PMID: 39793986 PMC: 11723785. DOI: 10.14814/phy2.70164.

Emerging roles of mechanosensitive ion channels in ventilator induced lung injury: a systematic review.

Liu G, Dong B, Devanarayana S, Chen R, Liu Q Front Immunol. 2024; 15:1479230.

PMID: 39664395 PMC: 11631737. DOI: 10.3389/fimmu.2024.1479230.

The neurobiology of thirst and salt appetite.

Grove J, Knight Z Neuron. 2024; 112(24):3999-4016.

PMID: 39610247 PMC: 11660113. DOI: 10.1016/j.neuron.2024.10.028.

The co-expression of the depolarizing and hyperpolarizing mechanosensitive ion channels in mammalian retinal neurons.

Pang V, Yang Z, Wu S, Pang J Front Med (Lausanne). 2024; 11:1463898.

PMID: 39606631 PMC: 11601153. DOI: 10.3389/fmed.2024.1463898.

References

Denton D, McKinley M, Weisinger R . Hypothalamic integration of body fluid regulation. Proc Natl Acad Sci U S A. 1996; 93(14):7397-404. PMC: 38996. DOI: 10.1073/pnas.93.14.7397. View

Bisley J, Rees S, McKinley M, Hards D, Oldfield B . Identification of osmoresponsive neurons in the forebrain of the rat: a Fos study at the ultrastructural level. Brain Res. 1996; 720(1-2):25-34. DOI: 10.1016/0006-8993(96)00079-0. View

Liedtke W, Edelmann W, Bieri P, Chiu F, Cowan N, Kucherlapati R . GFAP is necessary for the integrity of CNS white matter architecture and long-term maintenance of myelination. Neuron. 1996; 17(4):607-15. DOI: 10.1016/s0896-6273(00)80194-4. View

Babcock D, Herrington J, Goodwin P, Park Y, Hille B . Mitochondrial participation in the intracellular Ca2+ network. J Cell Biol. 1997; 136(4):833-44. PMC: 2132502. DOI: 10.1083/jcb.136.4.833. View

Bourque C, Oliet S . Osmoreceptors in the central nervous system. Annu Rev Physiol. 1997; 59:601-19. DOI: 10.1146/annurev.physiol.59.1.601. View

Colbert H, Smith T, Bargmann C . OSM-9, a novel protein with structural similarity to channels, is required for olfaction, mechanosensation, and olfactory adaptation in Caenorhabditis elegans. J Neurosci. 1997; 17(21):8259-69. PMC: 6573730. View

Caterina M, Schumacher M, Tominaga M, Rosen T, Levine J, Julius D . The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature. 1997; 389(6653):816-24. DOI: 10.1038/39807. View

Caldwell R, Clemo H, Baumgarten C . Using gadolinium to identify stretch-activated channels: technical considerations. Am J Physiol. 1998; 275(2):C619-21. DOI: 10.1152/ajpcell.1998.275.2.C619. View

Meyer J, Furness D, Zenner H, Hackney C, Gummer A . Evidence for opening of hair-cell transducer channels after tip-link loss. J Neurosci. 1998; 18(17):6748-56. PMC: 6792952. View

10.

Heller S, Sheane C, Javed Z, Hudspeth A . Molecular markers for cell types of the inner ear and candidate genes for hearing disorders. Proc Natl Acad Sci U S A. 1998; 95(19):11400-5. PMC: 21654. DOI: 10.1073/pnas.95.19.11400. View

11.

Dehnhardt G, Mauck B, Hyvarinen H . Ambient temperature does not affect the tactile sensitivity of mystacial vibrissae in harbour seals. J Exp Biol. 1998; 201(Pt 22):3023-9. DOI: 10.1242/jeb.201.22.3023. View

12.

McKinley M, Mathai M, Pennington G, Rundgren M, Vivas L . Effect of individual or combined ablation of the nuclear groups of the lamina terminalis on water drinking in sheep. Am J Physiol. 1999; 276(3):R673-83. DOI: 10.1152/ajpregu.1999.276.3.R673. View

13.

Caterina M, Rosen T, Tominaga M, Brake A, Julius D . A capsaicin-receptor homologue with a high threshold for noxious heat. Nature. 1999; 398(6726):436-41. DOI: 10.1038/18906. View

14.

Zygmunt P, Petersson J, Andersson D, Chuang H, Sorgard M, Di Marzo V . Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide. Nature. 1999; 400(6743):452-7. DOI: 10.1038/22761. View

15.

Kanzaki M, Nagasawa M, Kojima I, Sato C, Naruse K, Sokabe M . Molecular identification of a eukaryotic, stretch-activated nonselective cation channel. Science. 1999; 285(5429):882-6. DOI: 10.1126/science.285.5429.882. View

16.

Caterina M, Julius D . Sense and specificity: a molecular identity for nociceptors. Curr Opin Neurobiol. 1999; 9(5):525-30. DOI: 10.1016/S0959-4388(99)00009-4. View

17.

Retief J . Phylogenetic analysis using PHYLIP. Methods Mol Biol. 1999; 132:243-58. DOI: 10.1385/1-59259-192-2:243. View

18.

Touchman J, Anikster Y, Dietrich N, Maduro V, McDowell G, Shotelersuk V . The genomic region encompassing the nephropathic cystinosis gene (CTNS): complete sequencing of a 200-kb segment and discovery of a novel gene within the common cystinosis-causing deletion. Genome Res. 2000; 10(2):165-73. PMC: 310836. DOI: 10.1101/gr.10.2.165. View

19.

Harteneck C, Plant T, Schultz G . From worm to man: three subfamilies of TRP channels. Trends Neurosci. 2000; 23(4):159-66. DOI: 10.1016/s0166-2236(99)01532-5. View

20.

Walker R, Willingham A, Zuker C . A Drosophila mechanosensory transduction channel. Science. 2000; 287(5461):2229-34. DOI: 10.1126/science.287.5461.2229. View