Impact of Mycotoxins on Animals' Oxidative Status

Overview

Journal Antioxidants (Basel)

Date 2021 Feb 4

PMID 33535708

Citations 41

Authors

Alexandros Mavrommatis

Elisavet Giamouri

Savvina Tavrizelou

Maria Zacharioudaki

George Danezis

Panagiotis E Simitzis

Evangelos Zoidis

Eleni Tsiplakou

Athanasios C Pappas

Constantinos A Georgiou

Kostas Feggeros

Affiliations

Soon will be listed here.

Abstract

Mycotoxins appear to be the "Achilles' heel" of the agriculture sector inducing enormous economic losses and representing a severe risk to the health of humans and animals. Although novel determination protocols have been developed and legislation has been implemented within Europe, the side effects of mycotoxins on the homeostatic mechanisms of the animals have not been extensively considered. Feed mycotoxin contamination and the effects on the antioxidant status of livestock (poultry, swine, and ruminants) are presented. The findings support the idea that the antioxidant systems in both monogastrics and ruminants are challenged under the detrimental effect of mycotoxins by increasing the toxic lipid peroxidation by-product malondialdehyde (MDA) and inhibiting the activity of antioxidant defense mechanisms. The degree of oxidative stress is related to the duration of contamination, co-contamination, the synergetic effects, toxin levels, animal age, species, and productive stage. Since the damaging effects of MDA and other by-products derived by lipid peroxidation as well as reactive oxygen species have been extensively studied on human health, a more integrated monitoring mechanism (which will take into account the oxidative stability) is urgently required to be implemented in animal products.

Citing Articles

Reproductive Toxicity of Zearalenone and Its Molecular Mechanisms: A Review.

Lv Q, Xu W, Yang F, Wei W, Chen X, Zhang Z Molecules. 2025; 30(3).

PMID: 39942610 PMC: 11821083. DOI: 10.3390/molecules30030505.

Oxidative Stress in Poultry and the Therapeutic Role of Herbal Medicine in Intestinal Health.

Li Y, Wang K, Li C Antioxidants (Basel). 2024; 13(11).

PMID: 39594517 PMC: 11591273. DOI: 10.3390/antiox13111375.

Investigating the role of food pollutants in autism spectrum disorder: a comprehensive analysis of heavy metals, pesticides, and mycotoxins.

Nehzomi Z, Shirani K Naunyn Schmiedebergs Arch Pharmacol. 2024; .

PMID: 39466439 DOI: 10.1007/s00210-024-03551-4.

The Effect of Synbiotics and Probiotics on Ochratoxin Concentrations in Blood and Tissues, Health Status, and Gastrointestinal Function in Turkeys Fed Diets Contaminated with Ochratoxin A.

Mazur-Kusnirek M, Lipinski K, Antoszkiewicz Z, Slizewska K Animals (Basel). 2024; 14(20).

PMID: 39457953 PMC: 11505059. DOI: 10.3390/ani14203024.

Detection of Mycotoxin Contamination in Foods Using Artificial Intelligence: A Review.

Aggarwal A, Mishra A, Tabassum N, Kim Y, Khan F Foods. 2024; 13(20).

PMID: 39456400 PMC: 11507438. DOI: 10.3390/foods13203339.

References

Dupre-Crochet S, Erard M, NuBe O . ROS production in phagocytes: why, when, and where?. J Leukoc Biol. 2013; 94(4):657-70. DOI: 10.1189/jlb.1012544. View

Wu Q, Wang X, Yang W, Nussler A, Xiong L, Kuca K . Oxidative stress-mediated cytotoxicity and metabolism of T-2 toxin and deoxynivalenol in animals and humans: an update. Arch Toxicol. 2014; 88(7):1309-26. DOI: 10.1007/s00204-014-1280-0. View

Zhang J, Wang J, Fang H, Yu H, Zhao Y, Shen J . Pterostilbene inhibits deoxynivalenol-induced oxidative stress and inflammatory response in bovine mammary epithelial cells. Toxicon. 2020; 189:10-18. DOI: 10.1016/j.toxicon.2020.11.002. View

Pauletto M, Giantin M, Tolosi R, Bassan I, Barbarossa A, Zaghini A . Curcumin Mitigates AFB1-Induced Hepatic Toxicity by Triggering Cattle Antioxidant and Anti-inflammatory Pathways: A Whole Transcriptomic In Vitro Study. Antioxidants (Basel). 2020; 9(11). PMC: 7692341. DOI: 10.3390/antiox9111059. View

Wang J, Jin Y, Wu S, Yu H, Zhao Y, Fang H . Deoxynivalenol induces oxidative stress, inflammatory response and apoptosis in bovine mammary epithelial cells. J Anim Physiol Anim Nutr (Berl). 2019; 103(6):1663-1674. DOI: 10.1111/jpn.13180. View

Bernabucci U, Colavecchia L, Danieli P, Basirico L, Lacetera N, Nardone A . Aflatoxin B1 and fumonisin B1 affect the oxidative status of bovine peripheral blood mononuclear cells. Toxicol In Vitro. 2011; 25(3):684-91. DOI: 10.1016/j.tiv.2011.01.009. View

Rock C, Jacob R, Bowen P . Update on the biological characteristics of the antioxidant micronutrients: vitamin C, vitamin E, and the carotenoids. J Am Diet Assoc. 1996; 96(7):693-702; quiz 703-4. DOI: 10.1016/S0002-8223(96)00190-3. View

Sridhar M, Suganthi R, Thammiaha V . Effect of dietary resveratrol in ameliorating aflatoxin B1-induced changes in broiler birds. J Anim Physiol Anim Nutr (Berl). 2014; 99(6):1094-104. DOI: 10.1111/jpn.12260. View

Pandey I, Chauhan S . Studies on production performance and toxin residues in tissues and eggs of layer chickens fed on diets with various concentrations of aflatoxin AFB1. Br Poult Sci. 2007; 48(6):713-23. DOI: 10.1080/00071660701713534. View

10.

Galvano F, Piva A, Ritieni A, GALVANO G . Dietary strategies to counteract the effects of mycotoxins: a review. J Food Prot. 2001; 64(1):120-31. DOI: 10.4315/0362-028x-64.1.120. View

11.

HELL , Cardwell , Setamou , Poehling . The influence of storage practices on aflatoxin contamination in maize in four agroecological zones of Benin, west Africa. J Stored Prod Res. 2000; 36(4):365-382. DOI: 10.1016/s0022-474x(99)00056-9. View

12.

Raduly Z, Szabo L, Madar A, Pocsi I, Csernoch L . Toxicological and Medical Aspects of -Derived Mycotoxins Entering the Feed and Food Chain. Front Microbiol. 2020; 10:2908. PMC: 6962185. DOI: 10.3389/fmicb.2019.02908. View

13.

Hojnik N, Cvelbar U, Tavcar-Kalcher G, Walsh J, Krizaj I . Mycotoxin Decontamination of Food: Cold Atmospheric Pressure Plasma versus "Classic" Decontamination. Toxins (Basel). 2017; 9(5). PMC: 5450699. DOI: 10.3390/toxins9050151. View

14.

Wang Q, Zhang Y, Zheng N, Guo L, Song X, Zhao S . Biological System Responses of Dairy Cows to Aflatoxin B1 Exposure Revealed with Metabolomic Changes in Multiple Biofluids. Toxins (Basel). 2019; 11(2). PMC: 6410036. DOI: 10.3390/toxins11020077. View

15.

Huang S, Zheng N, Fan C, Cheng M, Wang S, Jabar A . Effects of aflatoxin B1 combined with ochratoxin A and/or zearalenone on metabolism, immune function, and antioxidant status in lactating dairy goats. Asian-Australas J Anim Sci. 2017; 31(4):505-513. PMC: 5838322. DOI: 10.5713/ajas.17.0279. View

16.

Gallo A, Giuberti G, Frisvad J, Bertuzzi T, Nielsen K . Review on Mycotoxin Issues in Ruminants: Occurrence in Forages, Effects of Mycotoxin Ingestion on Health Status and Animal Performance and Practical Strategies to Counteract Their Negative Effects. Toxins (Basel). 2015; 7(8):3057-111. PMC: 4549740. DOI: 10.3390/toxins7083057. View

17.

Strasser A, Carra M, Ghareeb K, Awad W, Bohm J . Protective effects of antioxidants on deoxynivalenol-induced damage in murine lymphoma cells. Mycotoxin Res. 2013; 29(3):203-8. DOI: 10.1007/s12550-013-0170-2. View

18.

Vidal A, Mengelers M, Yang S, De Saeger S, De Boevre M . Mycotoxin Biomarkers of Exposure: A Comprehensive Review. Compr Rev Food Sci Food Saf. 2020; 17(5):1127-1155. DOI: 10.1111/1541-4337.12367. View

19.

Fraeyman S, Croubels S, Devreese M, Antonissen G . Emerging Fusarium and Alternaria Mycotoxins: Occurrence, Toxicity and Toxicokinetics. Toxins (Basel). 2017; 9(7). PMC: 5535175. DOI: 10.3390/toxins9070228. View

20.

Van Le Thanh B, Lemay M, Bastien A, Lapointe J, Lessard M, Chorfi Y . The potential effects of antioxidant feed additives in mitigating the adverse effects of corn naturally contaminated with Fusarium mycotoxins on antioxidant systems in the intestinal mucosa, plasma, and liver in weaned pigs. Mycotoxin Res. 2016; 32(2):99-116. DOI: 10.1007/s12550-016-0245-y. View